DegronMD

Uniprot ID: Q6ZW49

Source protein: PAX-interacting protein 1

Source gene: PAXIP1

Class: LIG_APCC_ABBA_1

Location: 185:190

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5321

ASA_SCORE: 99.0833

COIL: 0.7748

CONS_SCORE: 0.3859

DSS_SCORE: 0.5992

HELIX: 0.1808

FCONS_SCORE: 0.9575

RIG_SCORE: 0.8074

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R184H	TCGA-09-2053	OV	TCGA	LIIYEE	LIG_APCC_ABBA_1	0.3056
p.R184H	DO31060	OV	ICGC	LIIYEE	LIG_APCC_ABBA_1	0.3056
p.R184H	SIDM00845	Burkitt's Lymphoma	GDSC	LIIYEE	LIG_APCC_ABBA_1	0.3056
p.R184H	ACH-000786	Lymphoma	CCLE	LIIYEE	LIG_APCC_ABBA_1	0.3056
p.R184H	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LIIYEE	LIG_APCC_ABBA_1	0.3056
p.E178K	TCGA-AA-A00N	COAD	TCGA	LIIYEE	LIG_APCC_ABBA_1	0.1389
p.E178K	DO9876	COAD	ICGC	LIIYEE	LIG_APCC_ABBA_1	0.1389
p.P183H	TCGA-AX-A05S	UCEC	TCGA	LIIYEE	LIG_APCC_ABBA_1	0.2778
p.P183H	DO43218	UCEC	ICGC	LIIYEE	LIG_APCC_ABBA_1	0.2778
p.R184C	TCGA-FR-A726	SKCM	TCGA	LIIYEE	LIG_APCC_ABBA_1	0.3056
p.R184C	TCGA-FW-A3R5	SKCM	TCGA	LIIYEE	LIG_APCC_ABBA_1	0.3056
p.R184C	DO37406	SKCM	ICGC	LIIYEE	LIG_APCC_ABBA_1	0.3056
p.R184C	DO48665	SKCM	ICGC	LIIYEE	LIG_APCC_ABBA_1	0.3056
p.E199V	DO222998	BTCA	ICGC	LIIYEE	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZW49	PAX-interacting protein 1	LIG_APCC_ABBA_1	185:190	LIIYEE	APC,CDC20,FZR1	0.5321	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons