DegronMD

Uniprot ID: Q93009

Source protein: Ubiquitin carboxyl-terminal hydrolase 7

Source gene: USP7

Class: LIG_APCC_ABBA_1

Location: 732:737

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7864

ASA_SCORE: 14.7333

COIL: 0.0765

CONS_SCORE: 0.5334

DSS_SCORE: 0.1083

HELIX: 0.0183

FCONS_SCORE: 1.3656

RIG_SCORE: 0.9013

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P740L	TCGA-06-5416	GBM	TCGA	LILYEE	LIG_APCC_ABBA_1	0.25
p.P740L	TCGA-BF-AAP7	SKCM	TCGA	LILYEE	LIG_APCC_ABBA_1	0.25
p.R723G	TCGA-B5-A3FA	UCEC	TCGA	LILYEE	LIG_APCC_ABBA_1	0.0833
p.D729Y	TCGA-BK-A6W3	UCEC	TCGA	LILYEE	LIG_APCC_ABBA_1	0.25
p.R723I	TCGA-D3-A3C8	SKCM	TCGA	LILYEE	LIG_APCC_ABBA_1	0.0833
p.R723I	DO47636	SKCM	ICGC	LILYEE	LIG_APCC_ABBA_1	0.0833
p.Y735C	TCGA-VQ-A91D	STAD	TCGA	LILYEE	LIG_APCC_ABBA_1	0.8198
p.R730S	DO25444	LUAD	ICGC	LILYEE	LIG_APCC_ABBA_1	0.7222
p.V735M	DO38328	STAD	ICGC	LILYEE	LIG_APCC_ABBA_1	0.7208
p.Q728L	SIDM00032	Bladder Carcinoma	GDSC	LILYEE	LIG_APCC_ABBA_1	0.2222
p.Q728L	ACH-000839	Bladder Cancer	CCLE	LILYEE	LIG_APCC_ABBA_1	0.2222
p.Q728L	SCaBER	urinary_tract	COSMIC	LILYEE	LIG_APCC_ABBA_1	0.2222
p.M745L	SHP-77	lung	COSMIC	LILYEE	LIG_APCC_ABBA_1	0.1111

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A827T (No)	GDSC	P22077	20.762
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.V990A (No)	GDSC	P22077	14.477
SIDM00499	PRAD\|prostate	p.A197V (No)	GDSC	P22077	438.46
SIDM00145	ALL\|lymphoblastic_leukemia	p.R239* (No)	GDSC	P22077	108.11
SIDM00683	PRAD\|prostate	p.E924K (No)	GDSC	P22077	5.6423
SIDM00683	PRAD\|prostate	p.G577D (No)	GDSC	P22077	5.6423
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.M761L (No)	GDSC	P22077	48.7
SIDM01007	ALL\|lymphoblastic_leukemia	p.R549M (No)	GDSC	P22077	19.941
SIDM01007	ALL\|lymphoblastic_leukemia	p.E345K (No)	GDSC	P22077	19.941
SIDM01007	ALL\|lymphoblastic_leukemia	p.V189F (No)	GDSC	P22077	19.941
SIDM01007	ALL\|lymphoblastic_leukemia	p.R104H (No)	GDSC	P22077	19.941
SIDM00312	MM\|myeloma	p.Q747* (Yes)	GDSC	P22077	94.018
SIDM01090	COREAD\|large_intestine	p.L540F (No)	GDSC	P22077	87.742
SIDM00485	HNSC\|head_and_neck	p.E495V (No)	GDSC	P22077	179.75
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.D58E (No)	GDSC	P22077	130.43
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.H3Q (No)	GDSC	P22077	130.43
SIDM00140	SKCM\|melanoma	p.P804L (No)	GDSC	P22077	74.268
SIDM01042	BRCA\|breast	p.S282L (No)	GDSC	P22077	6.595
SIDM00282	COREAD\|large_intestine	p.W205* (No)	GDSC	P22077	34.817
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.D198V (No)	GDSC	P22077	92.596
SIDM00150	COREAD\|large_intestine	p.A493V (No)	GDSC	P22077	25.415
SIDM00589	HNSC\|head_and_neck	p.H111Q (No)	GDSC	P22077	48.154
SIDM00789	COREAD\|large_intestine	p.A627S (No)	GDSC	P22077	38.286
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P694S (No)	GDSC	P22077	893.8
SIDM01081	HNSC\|head_and_neck	p.I354N (No)	GDSC	P22077	231.98
SIDM00277	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.Q372E (No)	GDSC	P22077	16.257

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q93009	Ubiquitin carboxyl-terminal hydrolase 7	LIG_APCC_ABBA_1	732:737	LILYEE	APC,CDC20,FZR1	0.7864	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LILYEE

Degron related mutations and impact score

Drug responses associated with USP7 mutations

All proteins holding degron of LILYEE