DegronMD

Uniprot ID: O95398

Source protein: Rap guanine nucleotide exchange factor 3

Source gene: RAPGEF3

Class: LIG_APCC_ABBA_1

Location: 641:646

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5091

ASA_SCORE: 71.4

COIL: 0.8152

CONS_SCORE: 0.4581

DSS_SCORE: 0.5321

HELIX: 0.0998

FCONS_SCORE: 0.9981

RIG_SCORE: 0.749

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L641P	TCGA-BC-A10R	LIHC	TCGA	LIPHPD	LIG_APCC_ABBA_1	0.7582
p.L641P	DO22962	LIHC	ICGC	LIPHPD	LIG_APCC_ABBA_1	0.7582
p.E640K	TCGA-KQ-A41O	BLCA	TCGA	LIPHPD	LIG_APCC_ABBA_1	0.3056
p.E640K	DO223589	BLCA	ICGC	LIPHPD	LIG_APCC_ABBA_1	0.3056
p.P650T	DO228976	LICA	ICGC	LIPHPD	LIG_APCC_ABBA_1	0.2222
p.N634H	DO229536	PRAD	ICGC	LIPHPD	LIG_APCC_ABBA_1	0.1389
p.R655Q	SNU-1040	large_intestine	COSMIC	LIPHPD	LIG_APCC_ABBA_1	0.0833
p.Y647C	NCI-H211	lung	COSMIC	LIPHPD	LIG_APCC_ABBA_1	0.3056
p.R640G	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LIPHPD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95398	Rap guanine nucleotide exchange factor 3	LIG_APCC_ABBA_1	641:646	LIPHPD	APC,CDC20,FZR1	0.5091	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons