DegronMD

Uniprot ID: P17544

Source protein: Cyclic AMP-dependent transcription factor ATF-7

Source gene: ATF7

Class: DEG_SCF_FBW7_1

Location: 142:149

E3 ligase: FBXW7

DEGRON score: 0.9971

ASA_SCORE: 78.975

COIL: 0.8949

CONS_SCORE: 0.3763

DSS_SCORE: 0.5426

HELIX: 0.0198

FCONS_SCORE: 0.8991

RIG_SCORE: 0.7104

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K134N	TCGA-53-7624	LUAD	TCGA	LISTPTPT	DEG_SCF_FBW7_1	0.2222
p.K134N	DO25058	LUAD	ICGC	LISTPTPT	DEG_SCF_FBW7_1	0.2222
p.V136A	TCGA-DA-A1I5	SKCM	TCGA	LISTPTPT	DEG_SCF_FBW7_1	0.1667
p.V136A	DO37447	SKCM	ICGC	LISTPTPT	DEG_SCF_FBW7_1	0.1667
p.S155F	TCGA-EB-A3XF	SKCM	TCGA	LISTPTPT	DEG_SCF_FBW7_1	0.1667
p.R152S	DO229045	LICA	ICGC	LISTPTPT	DEG_SCF_FBW7_1	0.25
p.R152H	DO32932	PACA	ICGC	LISTPTPT	DEG_SCF_FBW7_1	0.25
p.S136G	HEC-1	endometrium	COSMIC	LISTPTPT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17544	Cyclic AMP-dependent transcription factor ATF-7	DEG_SCF_FBW7_1	142:149	LISTPTPT	FBXW7	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons