DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LKDTPLYT
Uniprot ID:
Q6P2Q9
Source protein:
Pre-mRNA-processing-splicing factor 8
Source gene:
PRPF8
Class:
DEG_SCF_FBW7_1
Location:
388:395
E3 ligase:
FBXW7
DEGRON score:
0.9591
ASA_SCORE:
66.95
COIL:
0.787
CONS_SCORE:
0.5008
DSS_SCORE:
0.3615
HELIX:
0.094
FCONS_SCORE:
0.9406
RIG_SCORE:
0.808
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P392T
DO229253
THCA
ICGC
LKDTPLYT
DEG_SCF_FBW7_1
0.7031
p.A399S
ACH-000966
Ovarian Cancer
CCLE
LKDTPLYT
DEG_SCF_FBW7_1
0.2222
Drug responses associated with PRPF8 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LKDTPLYT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6P2Q9
Pre-mRNA-processing-splicing factor 8
DEG_SCF_FBW7_1
388:395
LKDTPLYT
FBXW7
0.9591
More...