DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
LKENW
Uniprot ID:
Q9H2J1
Source protein:
Uncharacterized protein ARRDC1-AS1
Source gene:
ARRDC1-AS1
Class:
DEG_APCC_KENBOX_2
Location:
59:63
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8258
ASA_SCORE:
49.6
COIL:
0.468
CONS_SCORE:
1
DSS_SCORE:
0.5978
HELIX:
0.246
FCONS_SCORE:
1.1
RIG_SCORE:
0.698
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ARRDC1-AS1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LKENW
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H2J1
Uncharacterized protein ARRDC1-AS1
DEG_APCC_KENBOX_2
59:63
LKENW
APC,CDC20,FZR1
0.8258
More...