DegronMD

Uniprot ID: P02748

Source protein: Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b]

Source gene: C9

Class: DEG_SCF_FBW7_1

Location: 241:248

E3 ligase: FBXW7

DEGRON score: 0.9801

ASA_SCORE: 60.65

COIL: 0.5755

CONS_SCORE: 0.5038

DSS_SCORE: 0.3418

HELIX: 0.0946

FCONS_SCORE: 1.488

RIG_SCORE: 0.7865

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P245T	TCGA-55-6970	LUAD	TCGA	LKFTPTET	DEG_SCF_FBW7_1	0.7031
p.P245T	DO24421	LUAD	ICGC	LKFTPTET	DEG_SCF_FBW7_1	0.7031
p.N236H	TCGA-A2-A0EW	BRCA	TCGA	LKFTPTET	DEG_SCF_FBW7_1	0.1944
p.N236H	DO1481	BRCA	ICGC	LKFTPTET	DEG_SCF_FBW7_1	0.1944
p.N234H	TCGA-AA-3984	COAD	TCGA	LKFTPTET	DEG_SCF_FBW7_1	0.1389
p.N234H	TCGA-D1-A17Q	UCEC	TCGA	LKFTPTET	DEG_SCF_FBW7_1	0.1389
p.N234H	DO9002	COAD	ICGC	LKFTPTET	DEG_SCF_FBW7_1	0.1389
p.N234H	DO41903	UCEC	ICGC	LKFTPTET	DEG_SCF_FBW7_1	0.1389
p.S240Y	TCGA-B5-A0JY	UCEC	TCGA	LKFTPTET	DEG_SCF_FBW7_1	0.3056
p.S240Y	DO43041	UCEC	ICGC	LKFTPTET	DEG_SCF_FBW7_1	0.3056
p.N234K	TCGA-BS-A0UF	UCEC	TCGA	LKFTPTET	DEG_SCF_FBW7_1	0.1389
p.N234K	DO41488	UCEC	ICGC	LKFTPTET	DEG_SCF_FBW7_1	0.1389
p.K242N	TCGA-CA-6717	COAD	TCGA	LKFTPTET	DEG_SCF_FBW7_1	0.5806
p.K242N	DO8264	COAD	ICGC	LKFTPTET	DEG_SCF_FBW7_1	0.5806
p.E257K	TCGA-EE-A3AE	SKCM	TCGA	LKFTPTET	DEG_SCF_FBW7_1	0.0833
p.E257K	DO222644	MELA	ICGC	LKFTPTET	DEG_SCF_FBW7_1	0.0833
p.E257K	DO37802	SKCM	ICGC	LKFTPTET	DEG_SCF_FBW7_1	0.0833
p.T246I	SIDM00660	Colorectal Carcinoma	GDSC	LKFTPTET	DEG_SCF_FBW7_1	0.5966
p.T246I	ACH-000985	Colon/Colorectal Cancer	CCLE	LKFTPTET	DEG_SCF_FBW7_1	0.5966
p.T246I	LS-411N	large_intestine	COSMIC	LKFTPTET	DEG_SCF_FBW7_1	0.5966

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P02748	Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b]	DEG_SCF_FBW7_1	241:248	LKFTPTET	FBXW7	0.9801	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons