DegronMD

Uniprot ID: P23743

Source protein: Diacylglycerol kinase alpha

Source gene: DGKA

Class: LIG_APCC_ABBA_1

Location: 57:62

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.652

ASA_SCORE: 52.9833

COIL: 0.2787

CONS_SCORE: 0.3786

DSS_SCORE: 0.0419

HELIX: 0.7112

FCONS_SCORE: 1.2316

RIG_SCORE: 0.9655

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L72M	TCGA-A5-A0G1	UCEC	TCGA	LKIYLE	LIG_APCC_ABBA_1	0.0556
p.L72M	DO42472	UCEC	ICGC	LKIYLE	LIG_APCC_ABBA_1	0.0556
p.A47V	TCGA-AX-A1CE	UCEC	TCGA	LKIYLE	LIG_APCC_ABBA_1	0.0556
p.A47V	DO229502	SKCA	ICGC	LKIYLE	LIG_APCC_ABBA_1	0.0556
p.A47V	DO42280	UCEC	ICGC	LKIYLE	LIG_APCC_ABBA_1	0.0556
p.F56V	DO10172	COAD	ICGC	LKIYLE	LIG_APCC_ABBA_1	0.3056
p.E62K	DO233115	GACA	ICGC	LKIYLE	LIG_APCC_ABBA_1	0.7022
p.E51D	DO229022	LICA	ICGC	LKIYLE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23743	Diacylglycerol kinase alpha	LIG_APCC_ABBA_1	57:62	LKIYLE	APC,CDC20,FZR1	0.652	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons