DegronMD

Uniprot ID: Q13114

Source protein: TNF receptor-associated factor 3

Source gene: TRAF3

Class: LIG_APCC_ABBA_1

Location: 19:24

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9473

ASA_SCORE: 106.6667

COIL: 0.895

CONS_SCORE: 0.5206

DSS_SCORE: 0.6398

HELIX: 0.0795

FCONS_SCORE: 0.9869

RIG_SCORE: 0.6954

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q14P	TCGA-23-2649	OV	TCGA	LKLHTD	LIG_APCC_ABBA_1	0.1944
p.Q14P	DO31779	OV	ICGC	LKLHTD	LIG_APCC_ABBA_1	0.1944
p.R25L	TCGA-AA-3947	COAD	TCGA	LKLHTD	LIG_APCC_ABBA_1	0.3056
p.R25L	DO8192	COAD	ICGC	LKLHTD	LIG_APCC_ABBA_1	0.3056
p.P18L	TCGA-AJ-A3OK	UCEC	TCGA	LKLHTD	LIG_APCC_ABBA_1	0.3056
p.P18L	DO43602	UCEC	ICGC	LKLHTD	LIG_APCC_ABBA_1	0.3056
p.T29M	TCGA-B5-A3FC	UCEC	TCGA	LKLHTD	LIG_APCC_ABBA_1	0.6389
p.T29M	TCGA-DU-6392	LGG	TCGA	LKLHTD	LIG_APCC_ABBA_1	0.6389
p.T29M	DO22237	LGG	ICGC	LKLHTD	LIG_APCC_ABBA_1	0.6389
p.T29M	DO41871	UCEC	ICGC	LKLHTD	LIG_APCC_ABBA_1	0.6389
p.S9F	TCGA-C5-A1MK	CESC	TCGA	LKLHTD	LIG_APCC_ABBA_1	0.5
p.S9F	TCGA-JW-A5VL	CESC	TCGA	LKLHTD	LIG_APCC_ABBA_1	0.5
p.S9F	DO49976	CESC	ICGC	LKLHTD	LIG_APCC_ABBA_1	0.5
p.S9F	DO6290	CESC	ICGC	LKLHTD	LIG_APCC_ABBA_1	0.5
p.P34T	TCGA-EE-A181	SKCM	TCGA	LKLHTD	LIG_APCC_ABBA_1	0.0556
p.P34T	DO37444	SKCM	ICGC	LKLHTD	LIG_APCC_ABBA_1	0.0556
p.P34S	TCGA-EE-A3AE	SKCM	TCGA	LKLHTD	LIG_APCC_ABBA_1	0.0556
p.P34S	DO37802	SKCM	ICGC	LKLHTD	LIG_APCC_ABBA_1	0.0556
p.T29P	DO222427	BTCA	ICGC	LKLHTD	LIG_APCC_ABBA_1	0.6389
p.A12T	SIDM01118	Small Cell Lung Carcinoma	GDSC	LKLHTD	LIG_APCC_ABBA_1	0.1389
p.A12T	SIDM01159	Other Sarcomas	GDSC	LKLHTD	LIG_APCC_ABBA_1	0.1389
p.A12T	SW872	soft_tissue	COSMIC	LKLHTD	LIG_APCC_ABBA_1	0.1389
p.A12T	NCI-H740	lung	COSMIC	LKLHTD	LIG_APCC_ABBA_1	0.1389
p.A27P	SIDM00316	Glioblastoma	GDSC	LKLHTD	LIG_APCC_ABBA_1	0.25
p.A27P	ACH-000469	Brain Cancer	CCLE	LKLHTD	LIG_APCC_ABBA_1	0.25
p.A27P	YH-13	central_nervous_system	COSMIC	LKLHTD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13114	TNF receptor-associated factor 3	LIG_APCC_ABBA_1	19:24	LKLHTD	APC,CDC20,FZR1	0.9473	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons