DegronMD

Uniprot ID: P40189

Source protein: Interleukin-6 receptor subunit beta

Source gene: IL6ST

Class: LIG_APCC_ABBA_1

Location: 289:294

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8849

ASA_SCORE: 52.7667

COIL: 0.7208

CONS_SCORE: 0.7295

DSS_SCORE: 0.1668

HELIX: 0.0197

FCONS_SCORE: 1.311

RIG_SCORE: 0.8728

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S279C	TCGA-BH-A0WA	BRCA	TCGA	LKPFTE	LIG_APCC_ABBA_1	0.0556
p.S279C	DO2897	BRCA	ICGC	LKPFTE	LIG_APCC_ABBA_1	0.0556
p.R281Q	TCGA-EO-A3AV	UCEC	TCGA	LKPFTE	LIG_APCC_ABBA_1	0.1111
p.R281Q	DO52412	UCEC	ICGC	LKPFTE	LIG_APCC_ABBA_1	0.1111
p.S279F	TCGA-ER-A19E	SKCM	TCGA	LKPFTE	LIG_APCC_ABBA_1	0.0556
p.S279F	TCGA-ZF-AA58	BLCA	TCGA	LKPFTE	LIG_APCC_ABBA_1	0.0556
p.S279F	DO219100	BLCA	ICGC	LKPFTE	LIG_APCC_ABBA_1	0.0556
p.S279F	DO47542	SKCM	ICGC	LKPFTE	LIG_APCC_ABBA_1	0.0556
p.R300H	TCGA-QK-A8ZB	HNSC	TCGA	LKPFTE	LIG_APCC_ABBA_1	0.1667
p.R300H	DO52100	HNSC	ICGC	LKPFTE	LIG_APCC_ABBA_1	0.1667
p.S282F	DO222504	MELA	ICGC	LKPFTE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40189	Interleukin-6 receptor subunit beta	LIG_APCC_ABBA_1	289:294	LKPFTE	APC,CDC20,FZR1	0.8849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons