DegronMD

Uniprot ID: P54646

Source protein: 5'-AMP-activated protein kinase catalytic subunit alpha-2

Source gene: PRKAA2

Class: LIG_APCC_ABBA_1

Location: 363:368

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9332

ASA_SCORE: 105.8667

COIL: 0.9675

CONS_SCORE: 0.2514

DSS_SCORE: 0.6263

HELIX: 0.015

FCONS_SCORE: 1.1265

RIG_SCORE: 0.5938

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D354Y	TCGA-55-8208	LUAD	TCGA	LKPHPE	LIG_APCC_ABBA_1	0.0833
p.D354Y	DO51192	LUAD	ICGC	LKPHPE	LIG_APCC_ABBA_1	0.0833
p.R369M	TCGA-AA-3858	COAD	TCGA	LKPHPE	LIG_APCC_ABBA_1	0.3056
p.R369M	DO10308	COAD	ICGC	LKPHPE	LIG_APCC_ABBA_1	0.3056
p.S377I	TCGA-AP-A051	UCEC	TCGA	LKPHPE	LIG_APCC_ABBA_1	0.5278
p.S377I	DO42673	UCEC	ICGC	LKPHPE	LIG_APCC_ABBA_1	0.5278
p.P361T	TCGA-BR-4361	STAD	TCGA	LKPHPE	LIG_APCC_ABBA_1	0.2778
p.P361T	DO38887	STAD	ICGC	LKPHPE	LIG_APCC_ABBA_1	0.2778
p.H358Y	TCGA-BR-8680	STAD	TCGA	LKPHPE	LIG_APCC_ABBA_1	0.1944
p.H358Y	DO47769	STAD	ICGC	LKPHPE	LIG_APCC_ABBA_1	0.1944
p.S377N	TCGA-DA-A1I1	SKCM	TCGA	LKPHPE	LIG_APCC_ABBA_1	0.5278
p.S377N	DO37966	SKCM	ICGC	LKPHPE	LIG_APCC_ABBA_1	0.5278
p.P367T	TCGA-DK-A3IL	BLCA	TCGA	LKPHPE	LIG_APCC_ABBA_1	0.5919
p.P367T	DO555	BLCA	ICGC	LKPHPE	LIG_APCC_ABBA_1	0.5919
p.H366Y	TCGA-EB-A5SG	SKCM	TCGA	LKPHPE	LIG_APCC_ABBA_1	0.6118
p.H366Y	DO48726	SKCM	ICGC	LKPHPE	LIG_APCC_ABBA_1	0.6118
p.P367L	TCGA-EB-A5UL	SKCM	TCGA	LKPHPE	LIG_APCC_ABBA_1	0.6471
p.P367L	DO47601	SKCM	ICGC	LKPHPE	LIG_APCC_ABBA_1	0.6471
p.E368Q	TCGA-FD-A43X	BLCA	TCGA	LKPHPE	LIG_APCC_ABBA_1	0.6744
p.E368Q	DO44067	BLCA	ICGC	LKPHPE	LIG_APCC_ABBA_1	0.6744
p.P378H	TCGA-FS-A1ZP	SKCM	TCGA	LKPHPE	LIG_APCC_ABBA_1	0.0556
p.P378H	DO37703	SKCM	ICGC	LKPHPE	LIG_APCC_ABBA_1	0.0556
p.L363P	TCGA-VQ-A92D	STAD	TCGA	LKPHPE	LIG_APCC_ABBA_1	0.7582
p.L363P	DO222366	STAD	ICGC	LKPHPE	LIG_APCC_ABBA_1	0.7582
p.A356V	TCGA-XK-AAIW	PRAD	TCGA	LKPHPE	LIG_APCC_ABBA_1	0.1389
p.A356V	DO51407	PRAD	ICGC	LKPHPE	LIG_APCC_ABBA_1	0.1389
p.D354N	DO229491	SKCA	ICGC	LKPHPE	LIG_APCC_ABBA_1	0.0833
p.P371T	SIDM00885	Breast Carcinoma	GDSC	LKPHPE	LIG_APCC_ABBA_1	0.25
p.P371T	ACH-000111	Breast Cancer	CCLE	LKPHPE	LIG_APCC_ABBA_1	0.25
p.P371T	HCC1187	breast	COSMIC	LKPHPE	LIG_APCC_ABBA_1	0.25
p.R369S	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	LKPHPE	LIG_APCC_ABBA_1	0.3056
p.R369S	ACH-000900	Lung Cancer	CCLE	LKPHPE	LIG_APCC_ABBA_1	0.3056
p.R369S	NCI-H23	lung	COSMIC	LKPHPE	LIG_APCC_ABBA_1	0.3056
p.P378L	ACH-002396	Bone Cancer	CCLE	LKPHPE	LIG_APCC_ABBA_1	0.0556
p.P378L	Sarc9371	bone	COSMIC	LKPHPE	LIG_APCC_ABBA_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LKPHPE

Degron related mutations and impact score

Drug responses associated with PRKAA2 mutations

All proteins holding degron of LKPHPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54646	5'-AMP-activated protein kinase catalytic subunit alpha-2	LIG_APCC_ABBA_1	363:368	LKPHPE	APC,CDC20,FZR1	0.9332	More...