DegronMD

Uniprot ID: P21709

Source protein: Ephrin type-A receptor 1

Source gene: EPHA1

Class: LIG_APCC_ABBA_1

Location: 596:601

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8843

ASA_SCORE: 57.9167

COIL: 0.683

CONS_SCORE: 0.6099

DSS_SCORE: 0.305

HELIX: 0.073

FCONS_SCORE: 1.218

RIG_SCORE: 0.8519

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D592G	TCGA-A5-A1OF	UCEC	TCGA	LKPYVD	LIG_APCC_ABBA_1	0.2222
p.D592G	DO42568	UCEC	ICGC	LKPYVD	LIG_APCC_ABBA_1	0.2222
p.Q610H	TCGA-E8-A2EA	THCA	TCGA	LKPYVD	LIG_APCC_ABBA_1	0.0833
p.Q610H	DO38926	THCA	ICGC	LKPYVD	LIG_APCC_ABBA_1	0.0833
p.P608T	DO229041	LICA	ICGC	LKPYVD	LIG_APCC_ABBA_1	0.1389
p.D587N	DO220894	MELA	ICGC	LKPYVD	LIG_APCC_ABBA_1	0.0833
p.D589N	DO222753	MELA	ICGC	LKPYVD	LIG_APCC_ABBA_1	0.1389
p.D607N	DO218898	SKCA	ICGC	LKPYVD	LIG_APCC_ABBA_1	0.1667
p.Q603L	DO229242	THCA	ICGC	LKPYVD	LIG_APCC_ABBA_1	0.2778
p.E606K	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LKPYVD	LIG_APCC_ABBA_1	0.1944
p.E606K	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LKPYVD	LIG_APCC_ABBA_1	0.1944
p.E606K	ACH-000995	Leukemia	CCLE	LKPYVD	LIG_APCC_ABBA_1	0.1944
p.E606K	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LKPYVD	LIG_APCC_ABBA_1	0.1944
p.P608H	ACH-000999	Colon/Colorectal Cancer	CCLE	LKPYVD	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P21709	Ephrin type-A receptor 1	LIG_APCC_ABBA_1	596:601	LKPYVD	APC,CDC20,FZR1	0.8843	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons