DegronMD

Uniprot ID: Q92538

Source protein: Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

Source gene: GBF1

Class: DEG_SCF_FBW7_1

Location: 1843:1850

E3 ligase: FBXW7

DEGRON score: 0.8257

ASA_SCORE: 89.925

COIL: 0.9123

CONS_SCORE: 0.2331

DSS_SCORE: 0.5158

HELIX: 0.0243

FCONS_SCORE: 1.1336

RIG_SCORE: 0.688

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1845S	TCGA-AA-3713	COAD	TCGA	LLATPRPT	DEG_SCF_FBW7_1	0.6477
p.A1845S	DO8400	COAD	ICGC	LLATPRPT	DEG_SCF_FBW7_1	0.6477
p.A1833V	TCGA-AX-A06L	UCEC	TCGA	LLATPRPT	DEG_SCF_FBW7_1	0.0556
p.A1833V	TCGA-DF-A2KU	UCEC	TCGA	LLATPRPT	DEG_SCF_FBW7_1	0.0556
p.A1833V	TCGA-EC-A24G	UCEC	TCGA	LLATPRPT	DEG_SCF_FBW7_1	0.0556
p.A1833V	DO230346	COCA	ICGC	LLATPRPT	DEG_SCF_FBW7_1	0.0556
p.A1833V	DO40996	UCEC	ICGC	LLATPRPT	DEG_SCF_FBW7_1	0.0556
p.A1833V	DO223286	UCEC	ICGC	LLATPRPT	DEG_SCF_FBW7_1	0.0556
p.A1833V	DO43851	UCEC	ICGC	LLATPRPT	DEG_SCF_FBW7_1	0.0556
p.A1833V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LLATPRPT	DEG_SCF_FBW7_1	0.0556
p.A1833V	ACH-001127	Leukemia	CCLE	LLATPRPT	DEG_SCF_FBW7_1	0.0556
p.A1833V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LLATPRPT	DEG_SCF_FBW7_1	0.0556
p.E1836K	TCGA-HU-8243	STAD	TCGA	LLATPRPT	DEG_SCF_FBW7_1	0.1389
p.E1836K	DO47915	STAD	ICGC	LLATPRPT	DEG_SCF_FBW7_1	0.1389
p.E1836K	SIDM00674	Non-Cancerous	GDSC	LLATPRPT	DEG_SCF_FBW7_1	0.1389
p.E1836K	ACH-002377	Non-Cancerous	CCLE	LLATPRPT	DEG_SCF_FBW7_1	0.1389
p.T1855I	DO227549	COCA	ICGC	LLATPRPT	DEG_SCF_FBW7_1	0.1944
p.R1848C	DO233766	GACA	ICGC	LLATPRPT	DEG_SCF_FBW7_1	0.719
p.R1848C	SIDM00502	B-Lymphoblastic Leukemia	GDSC	LLATPRPT	DEG_SCF_FBW7_1	0.719
p.R1848C	ACH-000157	Lymphoma	CCLE	LLATPRPT	DEG_SCF_FBW7_1	0.719
p.R1848C	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	LLATPRPT	DEG_SCF_FBW7_1	0.719
p.R1848H	SIDM02015	Colorectal Carcinoma	GDSC	LLATPRPT	DEG_SCF_FBW7_1	0.7133
p.R1848H	SIDM00783	Colorectal Carcinoma	GDSC	LLATPRPT	DEG_SCF_FBW7_1	0.7133
p.R1848H	ACH-000971	Colon/Colorectal Cancer	CCLE	LLATPRPT	DEG_SCF_FBW7_1	0.7133
p.P1849T	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	LLATPRPT	DEG_SCF_FBW7_1	0.5919
p.P1849T	ACH-000929	Lung Cancer	CCLE	LLATPRPT	DEG_SCF_FBW7_1	0.5919
p.P1849T	NCI-H2110	lung	COSMIC	LLATPRPT	DEG_SCF_FBW7_1	0.5919

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LLATPRPT

Degron related mutations and impact score

Drug responses associated with GBF1 mutations

All proteins holding degron of LLATPRPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92538	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1	DEG_SCF_FBW7_1	1843:1850	LLATPRPT	FBXW7	0.8257	More...