DegronMD

Uniprot ID: Q00535

Source protein: Cyclin-dependent kinase 5

Source gene: CDK5

Class: DEG_SCF_FBW7_2

Location: 218:225

E3 ligase: FBXW7

DEGRON score: 0.743

ASA_SCORE: 59.8

COIL: 0.6418

CONS_SCORE: 0.724

DSS_SCORE: 0.3508

HELIX: 0.3429

FCONS_SCORE: 1.1766

RIG_SCORE: 0.7364

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R217Q	TCGA-AX-A1C9	UCEC	TCGA	LLGTPTEE	DEG_SCF_FBW7_2	0.3056
p.R217Q	DO43098	UCEC	ICGC	LLGTPTEE	DEG_SCF_FBW7_2	0.3056
p.T221M	TCGA-CG-4306	STAD	TCGA	LLGTPTEE	DEG_SCF_FBW7_2	0.7423
p.T221M	DO233115	GACA	ICGC	LLGTPTEE	DEG_SCF_FBW7_2	0.7423
p.T221M	DO38567	STAD	ICGC	LLGTPTEE	DEG_SCF_FBW7_2	0.7423
p.P228L	TCGA-CV-7568	HNSC	TCGA	LLGTPTEE	DEG_SCF_FBW7_2	0.25
p.P228L	DO14160	HNSC	ICGC	LLGTPTEE	DEG_SCF_FBW7_2	0.25
p.K213E	DO233773	GACA	ICGC	LLGTPTEE	DEG_SCF_FBW7_2	0.6389
p.EE224DK	DO222550	MELA	ICGC	LLGTPTEE	DEG_SCF_FBW7_2	0.7022
p.D235G	DO233550	PRAD	ICGC	LLGTPTEE	DEG_SCF_FBW7_2	0.0556
p.T231A	SIDM00217	Colorectal Carcinoma	GDSC	LLGTPTEE	DEG_SCF_FBW7_2	0.6111
p.T231A	ACH-000999	Colon/Colorectal Cancer	CCLE	LLGTPTEE	DEG_SCF_FBW7_2	0.6111
p.T231A	SNU-1040	large_intestine	COSMIC	LLGTPTEE	DEG_SCF_FBW7_2	0.6111

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01188	PAAD\|pancreas	p.R120C (No)	GDSC	PHA-793887	6.4871
SIDM01188	PAAD\|pancreas	p.R120C (No)	GDSC	Dinaciclib	1.3741
SIDM01259	ALL\|lymphoblastic_leukemia	p.K75fs*7 (No)	GDSC	CGP-60474	0.3185
SIDM01259	ALL\|lymphoblastic_leukemia	p.K75fs*7 (No)	GDSC	PHA-793887	0.4854
SIDM01259	ALL\|lymphoblastic_leukemia	p.K75fs*7 (No)	GDSC	Dinaciclib	0.1399
SIDM01045	UCEC\|endometrium	p.L165M (No)	GDSC	PHA-793887	14.3685
SIDM01045	UCEC\|endometrium	p.L165M (No)	GDSC	Dinaciclib	0.0365
SIDM00217	COREAD\|large_intestine	p.T231A (Yes)	GDSC	PHA-793887	2.7884
SIDM00217	COREAD\|large_intestine	p.T231A (Yes)	GDSC	Dinaciclib	0.0529
SIDM00217	COREAD\|large_intestine	p.R200W (No)	GDSC	PHA-793887	2.7884
SIDM00217	COREAD\|large_intestine	p.R200W (No)	GDSC	Dinaciclib	0.0529
SIDM00363	LAML\|acute_myeloid_leukaemia	p.G138W (No)	GDSC	CGP-60474	0.669
SIDM00363	LAML\|acute_myeloid_leukaemia	p.G138W (No)	GDSC	PHA-793887	5.3835
SIDM00789	COREAD\|large_intestine	p.G138E (No)	GDSC	PHA-793887	164.3388
SIDM00789	COREAD\|large_intestine	p.G138E (No)	GDSC	Dinaciclib	0.0351
SIDM00789	COREAD\|large_intestine	p.K56N (No)	GDSC	PHA-793887	164.3388
SIDM00789	COREAD\|large_intestine	p.K56N (No)	GDSC	Dinaciclib	0.0351
SIDM00317	KIRC\|kidney	p.R120C (No)	GDSC	PHA-793887	28.3314
SIDM00317	KIRC\|kidney	p.R120C (No)	GDSC	Dinaciclib	1.1202
SIDM00373	UCEC\|endometrium	p.R149* (No)	GDSC	PHA-793887	1.3201
SIDM00373	UCEC\|endometrium	p.R149* (No)	GDSC	Dinaciclib	0.0256

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q00535	Cyclin-dependent kinase 5	DEG_SCF_FBW7_2	218:225	LLGTPTEE	FBXW7	0.743	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons