DegronMD

Uniprot ID: Q9C0C7

Source protein: Activating molecule in BECN1-regulated autophagy protein 1

Source gene: AMBRA1

Class: LIG_APCC_ABBA_1

Location: 322:327

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6343

ASA_SCORE: 94.6833

COIL: 0.9002

CONS_SCORE: 0.3748

DSS_SCORE: 0.4381

HELIX: 0.0508

FCONS_SCORE: 1.0266

RIG_SCORE: 0.6983

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E328K	TCGA-30-1855	OV	TCGA	LLPHQD	LIG_APCC_ABBA_1	0.75
p.E328K	DO32666	OV	ICGC	LLPHQD	LIG_APCC_ABBA_1	0.75
p.S327A	TCGA-BR-4368	STAD	TCGA	LLPHQD	LIG_APCC_ABBA_1	0.7588
p.S327A	DO38715	STAD	ICGC	LLPHQD	LIG_APCC_ABBA_1	0.7588
p.G323V	TCGA-CG-5721	STAD	TCGA	LLPHQD	LIG_APCC_ABBA_1	0.7532
p.G323V	TCGA-L5-A8NM	ESCA	TCGA	LLPHQD	LIG_APCC_ABBA_1	0.7532
p.G323V	DO38192	STAD	ICGC	LLPHQD	LIG_APCC_ABBA_1	0.7532
p.R331Q	TCGA-GN-A263	SKCM	TCGA	LLPHQD	LIG_APCC_ABBA_1	0.2222
p.R331Q	DO37766	SKCM	ICGC	LLPHQD	LIG_APCC_ABBA_1	0.2222
p.R331Q	ACH-002222	Leukemia	CCLE	LLPHQD	LIG_APCC_ABBA_1	0.2222
p.R331Q	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	LLPHQD	LIG_APCC_ABBA_1	0.2222
p.E328Q	TCGA-Q1-A73P	CESC	TCGA	LLPHQD	LIG_APCC_ABBA_1	0.75
p.E328Q	DO49983	CESC	ICGC	LLPHQD	LIG_APCC_ABBA_1	0.75
p.S333C	DO1071	BRCA	ICGC	LLPHQD	LIG_APCC_ABBA_1	0.1667
p.S333F	DO234466	ESAD	ICGC	LLPHQD	LIG_APCC_ABBA_1	0.1667
p.L322I	DO26758	LUSC	ICGC	LLPHQD	LIG_APCC_ABBA_1	0.6063
p.S328N	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LLPHQD	LIG_APCC_ABBA_1	0.75
p.S328N	ACH-002272	Lymphoma	CCLE	LLPHQD	LIG_APCC_ABBA_1	0.75
p.S328N	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LLPHQD	LIG_APCC_ABBA_1	0.75
p.A336T	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	LLPHQD	LIG_APCC_ABBA_1	0.0833
p.A336T	SIDM01551	Gastric Carcinoma	GDSC	LLPHQD	LIG_APCC_ABBA_1	0.0833
p.A336T	ACH-000485	Gastric Cancer	CCLE	LLPHQD	LIG_APCC_ABBA_1	0.0833
p.A336T	ACH-000823	Esophageal Cancer	CCLE	LLPHQD	LIG_APCC_ABBA_1	0.0833
p.G326R	ACH-001999	Pancreatic Cancer	CCLE	LLPHQD	LIG_APCC_ABBA_1	0.7568

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0C7	Activating molecule in BECN1-regulated autophagy protein 1	LIG_APCC_ABBA_1	322:327	LLPHQD	APC,CDC20,FZR1	0.6343	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons