DegronMD

Uniprot ID: Q9UGR2

Source protein: Zinc finger CCCH domain-containing protein 7B

Source gene: ZC3H7B

Class: LIG_APCC_ABBA_1

Location: 351:356

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9911

ASA_SCORE: 72.0333

COIL: 0.7702

CONS_SCORE: 0.5231

DSS_SCORE: 0.4336

HELIX: 0.1703

FCONS_SCORE: 0.8655

RIG_SCORE: 0.785

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S355L	TCGA-BA-4074	HNSC	TCGA	LLPYSE	LIG_APCC_ABBA_1	0.6556
p.S355L	DO14710	HNSC	ICGC	LLPYSE	LIG_APCC_ABBA_1	0.6556
p.P353L	TCGA-EA-A410	CESC	TCGA	LLPYSE	LIG_APCC_ABBA_1	0.6471
p.P353L	DO49929	CESC	ICGC	LLPYSE	LIG_APCC_ABBA_1	0.6471
p.D350G	DO222877	COCA	ICGC	LLPYSE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UGR2	Zinc finger CCCH domain-containing protein 7B	LIG_APCC_ABBA_1	351:356	LLPYSE	APC,CDC20,FZR1	0.9911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons