DegronMD

Uniprot ID: P15407

Source protein: Fos-related antigen 1

Source gene: FOSL1

Class: DEG_SCF_FBW7_1

Location: 220:227

E3 ligase: FBXW7

DEGRON score: 0.9813

ASA_SCORE: 85.4

COIL: 0.8939

CONS_SCORE: 1

DSS_SCORE: 0.4556

HELIX: 0.0161

FCONS_SCORE: 1.0204

RIG_SCORE: 0.7278

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R213P	DO44423	HNSC	ICGC	LMTTPSLT	DEG_SCF_FBW7_1	0.1389
p.A211T	DO26465	LUSC	ICGC	LMTTPSLT	DEG_SCF_FBW7_1	0.0833
p.R213C	DO41380	UCEC	ICGC	LMTTPSLT	DEG_SCF_FBW7_1	0.1389
p.S232I	SIDM00690	Head and Neck Carcinoma	GDSC	LMTTPSLT	DEG_SCF_FBW7_1	0.1944
p.S232I	JHU-029	upper_aerodigestive_tract	COSMIC	LMTTPSLT	DEG_SCF_FBW7_1	0.1944
p.T230P	SCC-15	upper_aerodigestive_tract	COSMIC	LMTTPSLT	DEG_SCF_FBW7_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15407	Fos-related antigen 1	DEG_SCF_FBW7_1	220:227	LMTTPSLT	FBXW7	0.9813	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons