DegronMD

Uniprot ID: Q05397

Source protein: Focal adhesion kinase 1

Source gene: PTK2

Class: DEG_SCF_FBW7_1

Location: 10:17

E3 ligase: FBXW7

DEGRON score: 0.9778

ASA_SCORE: 70.8125

COIL: 0.9061

CONS_SCORE: 0.2593

DSS_SCORE: 0.6039

HELIX: 0.0579

FCONS_SCORE: 0.8164

RIG_SCORE: 0.6143

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L6V	TCGA-29-1698	OV	TCGA	LNHTPNSS	DEG_SCF_FBW7_1	0.6667
p.L6V	DO28531	OV	ICGC	LNHTPNSS	DEG_SCF_FBW7_1	0.6667
p.S16L	TCGA-AP-A1E0	UCEC	TCGA	LNHTPNSS	DEG_SCF_FBW7_1	0.7667
p.S16L	TCGA-D1-A16X	UCEC	TCGA	LNHTPNSS	DEG_SCF_FBW7_1	0.7667
p.S16L	TCGA-E6-A1LX	UCEC	TCGA	LNHTPNSS	DEG_SCF_FBW7_1	0.7667
p.S16L	DO8730	COAD	ICGC	LNHTPNSS	DEG_SCF_FBW7_1	0.7667
p.S16L	DO41020	UCEC	ICGC	LNHTPNSS	DEG_SCF_FBW7_1	0.7667
p.S16L	DO43154	UCEC	ICGC	LNHTPNSS	DEG_SCF_FBW7_1	0.7667
p.S16L	DO41799	UCEC	ICGC	LNHTPNSS	DEG_SCF_FBW7_1	0.7667
p.S16L	SIDM01043	Other Sarcomas	GDSC	LNHTPNSS	DEG_SCF_FBW7_1	0.7667
p.S16L	ACH-000913	Endometrial/Uterine Cancer	CCLE	LNHTPNSS	DEG_SCF_FBW7_1	0.7667
p.S16L	ESS-1	endometrium	COSMIC	LNHTPNSS	DEG_SCF_FBW7_1	0.7667
p.A2T	TCGA-CM-5861	COAD	TCGA	LNHTPNSS	DEG_SCF_FBW7_1	0.5556
p.A2T	DO7918	COAD	ICGC	LNHTPNSS	DEG_SCF_FBW7_1	0.5556
p.H12Y	TCGA-IR-A3LA	CESC	TCGA	LNHTPNSS	DEG_SCF_FBW7_1	0.6118
p.H12Y	DO44377	CESC	ICGC	LNHTPNSS	DEG_SCF_FBW7_1	0.6118
p.P14T	TCGA-IS-A3KA	SARC	TCGA	LNHTPNSS	DEG_SCF_FBW7_1	0.7031
p.P14T	DO220172	SARC	ICGC	LNHTPNSS	DEG_SCF_FBW7_1	0.7031
p.S15F	DO51925	BLCA	ICGC	LNHTPNSS	DEG_SCF_FBW7_1	0.7982
p.S11Y	DO457	BLCA	ICGC	LNHTPNSS	DEG_SCF_FBW7_1	0.712
p.I14K	DO227987	COCA	ICGC	LNHTPNSS	DEG_SCF_FBW7_1	0.7531
p.Y12H	DO224761	COCA	ICGC	LNHTPNSS	DEG_SCF_FBW7_1	0.7229
p.P25S	DO50357	ESAD	ICGC	LNHTPNSS	DEG_SCF_FBW7_1	0.1111
p.D7G	DO233089	GACA	ICGC	LNHTPNSS	DEG_SCF_FBW7_1	0.25
p.S15Y	DO46657	PAAD	ICGC	LNHTPNSS	DEG_SCF_FBW7_1	0.712
p.S17Y	DO41133	UCEC	ICGC	LNHTPNSS	DEG_SCF_FBW7_1	0.712
p.N15S	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LNHTPNSS	DEG_SCF_FBW7_1	0.5958

Drug responses associated with PTK2 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00210	UNCLASSIFIED\|ovary	p.S677G (No)	GDSC	PF-562271	3.2891
SIDM00087	MM\|myeloma	p.P731S (No)	GDSC	PF-562271	12.713
SIDM01073	UNCLASSIFIED\|hairy_cell_leukaemia	p.W613* (No)	GDSC	PF-562271	5.748
SIDM00381	CESC\|cervix	p.L1046P (No)	GDSC	PF-562271	11.5217
SIDM01090	COREAD\|large_intestine	p.P410H (No)	GDSC	PF-562271	2.6324
SIDM00995	UNCLASSIFIED\|skin_other	p.S745fs*36 (No)	GDSC	PF-562271	1.6673
SIDM00995	UNCLASSIFIED\|skin_other	p.M33fs*5 (No)	GDSC	PF-562271	1.6673
SIDM00516	SKCM\|melanoma	p.E809K (No)	GDSC	PF-562271	8.1771
SIDM01043	UNCLASSIFIED\|endometrium	p.S16L (Yes)	GDSC	PF-562271	4.0506
SIDM00518	MESO\|mesothelioma	p.A533S (No)	GDSC	PF-562271	5.77
SIDM00716	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.E544K (No)	GDSC	PF-562271	7.4519
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.S517C (No)	GDSC	PF-562271	43.9575
SIDM00889	CESC\|cervix	p.S307I (No)	GDSC	PF-562271	2.3525
SIDM00596	UCEC\|endometrium	p.S887N (No)	GDSC	PF-562271	7.126
SIDM00150	COREAD\|large_intestine	p.P116S (No)	GDSC	PF-562271	0.4899
SIDM00660	COREAD\|large_intestine	p.R811H (No)	GDSC	PF-562271	4.0457
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.N46S (No)	GDSC	PF-562271	8.6162
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.N15S (Yes)	GDSC	PF-562271	8.6162
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.I21R (Yes)	GDSC	PF-562271	8.6162
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.I1038V (No)	GDSC	PF-562271	17.7554
SIDM00789	COREAD\|large_intestine	p.P2H (Yes)	GDSC	PF-562271	37.2504
SIDM00534	COREAD\|large_intestine	p.R597* (No)	GDSC	PF-562271	7.9391
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.C459G (No)	GDSC	PF-562271	5.5512
SIDM00414	BLCA\|bladder	p.C74W (No)	GDSC	PF-562271	3.2423
SIDM00480	OV\|ovary	p.R841Q (No)	GDSC	PF-562271	19.8104
SIDM00545	SKCM\|melanoma	p.P70S (No)	GDSC	PF-562271	60.8052
SIDM00448	DLBC\|B_cell_lymphoma	p.A551T (No)	GDSC	PF-562271	14.3947
SIDM00528	BRCA\|breast	p.F669L (No)	GDSC	PF-562271	10.9497
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.P733T (No)	GDSC	PF-562271	3.2754
SIDM00133	LUAD\|lung_NSCLC_adenocarcinoma	p.S522C (No)	GDSC	PF-562271	2.7144
SIDM01040	OV\|ovary	p.T979S (No)	GDSC	PF-562271	10.1862
SIDM00556	NB\|neuroblastoma	p.L1046P (No)	GDSC	PF-562271	20.8426
SIDM00118	COREAD\|large_intestine	p.Y548D (No)	GDSC	PF-562271	3.5879

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LNHTPNSS

Degron related mutations and impact score

Drug responses associated with PTK2 mutations

All proteins holding degron of LNHTPNSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q05397	Focal adhesion kinase 1	DEG_SCF_FBW7_1	10:17	LNHTPNSS	FBXW7	0.9778	More...