DegronMD

Uniprot ID: Q6VMQ6

Source protein: Activating transcription factor 7-interacting protein 1

Source gene: ATF7IP

Class: DEG_SCF_FBW7_1

Location: 985:992

E3 ligase: FBXW7

DEGRON score: 0.9459

ASA_SCORE: 95.15

COIL: 0.9153

CONS_SCORE: 0.4785

DSS_SCORE: 0.7312

HELIX: 0.0294

FCONS_SCORE: 1.007

RIG_SCORE: 0.6109

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1001Q	TCGA-A8-A08O	BRCA	TCGA	LNHTPVST	DEG_SCF_FBW7_1	0.0833
p.H987N	TCGA-AG-A002	READ	TCGA	LNHTPVST	DEG_SCF_FBW7_1	0.6312
p.D981Y	TCGA-BR-4280	STAD	TCGA	LNHTPVST	DEG_SCF_FBW7_1	0.2222
p.D981A	TCGA-DD-A3A7	LIHC	TCGA	LNHTPVST	DEG_SCF_FBW7_1	0.2222
p.S976C	TCGA-WQ-A9G7	LIHC	TCGA	LNHTPVST	DEG_SCF_FBW7_1	0.5278
p.R1000Q	DO2311	BRCA	ICGC	LNHTPVST	DEG_SCF_FBW7_1	0.1111
p.V989L	DO228985	LICA	ICGC	LNHTPVST	DEG_SCF_FBW7_1	0.6765
p.D980A	DO44982	LIHC	ICGC	LNHTPVST	DEG_SCF_FBW7_1	0.1944
p.S975C	DO52326	LIHC	ICGC	LNHTPVST	DEG_SCF_FBW7_1	0.0556
p.D980Y	DO38663	STAD	ICGC	LNHTPVST	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SCF_FBW7_1	985:992	LNHTPVST	FBXW7	0.9459	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons