DegronMD

Uniprot ID: Q13761

Source protein: Runt-related transcription factor 3

Source gene: RUNX3

Class: LIG_APCC_ABBA_1

Location: 239:244

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9839

ASA_SCORE: 30.45

COIL: 0.8937

CONS_SCORE: 0.3542

DSS_SCORE: 0.7226

HELIX: 0.0328

FCONS_SCORE: 1.0483

RIG_SCORE: 0.662

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P246T	TCGA-BF-A1PZ	SKCM	TCGA	LNPFSD	LIG_APCC_ABBA_1	0.2778
p.P246T	DO50279	SKCM	ICGC	LNPFSD	LIG_APCC_ABBA_1	0.2778
p.Q244K	TCGA-CN-6010	HNSC	TCGA	LNPFSD	LIG_APCC_ABBA_1	0.6944
p.Q244K	DO14766	HNSC	ICGC	LNPFSD	LIG_APCC_ABBA_1	0.6944
p.P246Q	TCGA-DA-A1I1	SKCM	TCGA	LNPFSD	LIG_APCC_ABBA_1	0.2778
p.P246Q	DO37966	SKCM	ICGC	LNPFSD	LIG_APCC_ABBA_1	0.2778
p.S237R	DO229038	LICA	ICGC	LNPFSD	LIG_APCC_ABBA_1	0.2778
p.S237R	DO229272	THCA	ICGC	LNPFSD	LIG_APCC_ABBA_1	0.2778
p.R230Q	DO48899	PBCA	ICGC	LNPFSD	LIG_APCC_ABBA_1	0.0833
p.S234G	DO229268	THCA	ICGC	LNPFSD	LIG_APCC_ABBA_1	0.1944
p.F239L	SIDM00428	Acute Myeloid Leukemia	GDSC	LNPFSD	LIG_APCC_ABBA_1	0.6981
p.F239L	ACH-000294	Leukemia	CCLE	LNPFSD	LIG_APCC_ABBA_1	0.6981
p.F239L	NB-4	haematopoietic_and_lymphoid_tissue	COSMIC	LNPFSD	LIG_APCC_ABBA_1	0.6981
p.P243A	SIDM00845	Burkitt's Lymphoma	GDSC	LNPFSD	LIG_APCC_ABBA_1	0.7503
p.T235P	ACH-001307	Thyroid Cancer	CCLE	LNPFSD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13761	Runt-related transcription factor 3	LIG_APCC_ABBA_1	239:244	LNPFSD	APC,CDC20,FZR1	0.9839	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons