DegronMD

Uniprot ID: Q13127

Source protein: RE1-silencing transcription factor

Source gene: REST

Class: DEG_SCF_FBW7_2

Location: 926:932

E3 ligase: FBXW7

DEGRON score: 0.9977

ASA_SCORE: 76.9571

COIL: 0.8459

CONS_SCORE: 0.4553

DSS_SCORE: 0.6639

HELIX: 0.0461

FCONS_SCORE: 1.3541

RIG_SCORE: 0.6127

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T928M	TCGA-27-2519	GBM	TCGA	LNTPEGE	DEG_SCF_FBW7_2	0.7423
p.T928M	DO233156	GACA	ICGC	LNTPEGE	DEG_SCF_FBW7_2	0.7423
p.T928M	DO12790	GBM	ICGC	LNTPEGE	DEG_SCF_FBW7_2	0.7423
p.E932K	TCGA-56-8309	LUSC	TCGA	LNTPEGE	DEG_SCF_FBW7_2	0.7022
p.E932K	DO219141	LUSC	ICGC	LNTPEGE	DEG_SCF_FBW7_2	0.7022
p.E932K	DO27885	ORCA	ICGC	LNTPEGE	DEG_SCF_FBW7_2	0.7022
p.N935H	TCGA-AP-A1E0	UCEC	TCGA	LNTPEGE	DEG_SCF_FBW7_2	0.25
p.N935H	DO43154	UCEC	ICGC	LNTPEGE	DEG_SCF_FBW7_2	0.25
p.S920L	TCGA-D3-A1Q6	SKCM	TCGA	LNTPEGE	DEG_SCF_FBW7_2	0.1667
p.S920L	DO37450	SKCM	ICGC	LNTPEGE	DEG_SCF_FBW7_2	0.1667
p.S920L	SIDM00383	Gastric Carcinoma	GDSC	LNTPEGE	DEG_SCF_FBW7_2	0.1667
p.S920L	ACH-002198	Gastric Cancer	CCLE	LNTPEGE	DEG_SCF_FBW7_2	0.1667
p.S920L	SCH	stomach	COSMIC	LNTPEGE	DEG_SCF_FBW7_2	0.1667
p.P929S	TCGA-DA-A95X	SKCM	TCGA	LNTPEGE	DEG_SCF_FBW7_2	0.6752
p.P929S	DO219480	SKCM	ICGC	LNTPEGE	DEG_SCF_FBW7_2	0.6752
p.S916T	TCGA-E9-A1R7	BRCA	TCGA	LNTPEGE	DEG_SCF_FBW7_2	0.0556
p.S916T	DO1978	BRCA	ICGC	LNTPEGE	DEG_SCF_FBW7_2	0.0556
p.L934F	TCGA-P4-A5E7	KIRP	TCGA	LNTPEGE	DEG_SCF_FBW7_2	0.2778
p.L934F	DO48479	KIRP	ICGC	LNTPEGE	DEG_SCF_FBW7_2	0.2778
p.T940S	SIDM00678	Bladder Carcinoma	GDSC	LNTPEGE	DEG_SCF_FBW7_2	0.1111
p.T940S	ACH-000724	Bladder Cancer	CCLE	LNTPEGE	DEG_SCF_FBW7_2	0.1111
p.T940S	HT-1376	urinary_tract	COSMIC	LNTPEGE	DEG_SCF_FBW7_2	0.1111
p.D941H	SIDM00146	Breast Carcinoma	GDSC	LNTPEGE	DEG_SCF_FBW7_2	0.0833
p.D941H	ACH-000768	Breast Cancer	CCLE	LNTPEGE	DEG_SCF_FBW7_2	0.0833
p.D941H	MDA-MB-231	breast	COSMIC	LNTPEGE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13127	RE1-silencing transcription factor	DEG_SCF_FBW7_2	926:932	LNTPEGE	FBXW7	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons