DegronMD

Uniprot ID: Q92643

Source protein: GPI-anchor transamidase

Source gene: PIGK

Class: LIG_APCC_ABBA_1

Location: 110:115

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6614

ASA_SCORE: 54.6167

COIL: 0.6262

CONS_SCORE: 0.6025

DSS_SCORE: 0.2362

HELIX: 0.1967

FCONS_SCORE: 1.3518

RIG_SCORE: 0.7879

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N111I	DO230974	LUSC	ICGC	LNVYGD	LIG_APCC_ABBA_1	0.6169
p.N111I	DO224632	LUSC	ICGC	LNVYGD	LIG_APCC_ABBA_1	0.6169
p.E118D	TCGA-AX-A0J0	UCEC	TCGA	LNVYGD	LIG_APCC_ABBA_1	0.25
p.E118D	DO41133	UCEC	ICGC	LNVYGD	LIG_APCC_ABBA_1	0.25
p.V102L	TCGA-06-5416	GBM	TCGA	LNVYGD	LIG_APCC_ABBA_1	0.1111
p.V102L	DO10880	GBM	ICGC	LNVYGD	LIG_APCC_ABBA_1	0.1111
p.E125K	SIDM00955	Melanoma	GDSC	LNVYGD	LIG_APCC_ABBA_1	0.0556
p.E125K	ACH-000812	Skin Cancer	CCLE	LNVYGD	LIG_APCC_ABBA_1	0.0556
p.E125K	ACH-001001	Bone Cancer	CCLE	LNVYGD	LIG_APCC_ABBA_1	0.0556
p.E125K	COLO-783	skin	COSMIC	LNVYGD	LIG_APCC_ABBA_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92643	GPI-anchor transamidase	LIG_APCC_ABBA_1	110:115	LNVYGD	APC,CDC20,FZR1	0.6614	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons