DegronMD

Uniprot ID: Q8NA70

Source protein: Protein FAM47B

Source gene: FAM47B

Class: DEG_SCF_FBW7_1

Location: 203:210

E3 ligase: FBXW7

DEGRON score: 0.95

ASA_SCORE: 99.6

COIL: 0.9651

CONS_SCORE: 0.4615

DSS_SCORE: 0.7615

HELIX: 0.0143

FCONS_SCORE: 1.0031

RIG_SCORE: 0.5811

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R211H	TCGA-06-5416	GBM	TCGA	LPKTPVSS	DEG_SCF_FBW7_1	0.3056
p.R211H	TCGA-FP-A9TM	STAD	TCGA	LPKTPVSS	DEG_SCF_FBW7_1	0.3056
p.R211H	DO10880	GBM	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.3056
p.R211H	DO222332	STAD	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.3056
p.R212S	TCGA-86-8056	LUAD	TCGA	LPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.R212S	DO24950	LUAD	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.P195L	TCGA-A6-2685	COAD	TCGA	LPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.P195L	TCGA-CL-5918	READ	TCGA	LPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.P195L	DO225219	BRCA	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.P195L	DO10108	COAD	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.P195L	DO222395	MELA	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.P195L	DO36867	READ	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.R212C	TCGA-AG-3885	READ	TCGA	LPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.R212C	TCGA-DK-A6B6	BLCA	TCGA	LPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.R212C	DO48576	BLCA	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.R212C	DO36619	READ	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.R200C	TCGA-D3-A8GI	SKCM	TCGA	LPKTPVSS	DEG_SCF_FBW7_1	0.25
p.R200C	TCGA-D3-A8GN	SKCM	TCGA	LPKTPVSS	DEG_SCF_FBW7_1	0.25
p.R200C	DO50284	SKCM	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.25
p.R200C	DO51240	SKCM	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.25
p.R200C	ACH-001677	Lymphoma	CCLE	LPKTPVSS	DEG_SCF_FBW7_1	0.25
p.R198H	TCGA-EA-A3HS	CESC	TCGA	LPKTPVSS	DEG_SCF_FBW7_1	0.1944
p.R198H	DO6260	CESC	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.1944
p.R198H	DO49193	PACA	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.1944
p.R219W	TCGA-EE-A3AG	SKCM	TCGA	LPKTPVSS	DEG_SCF_FBW7_1	0.0833
p.R219W	TCGA-G4-6586	COAD	TCGA	LPKTPVSS	DEG_SCF_FBW7_1	0.0833
p.R219W	DO9698	COAD	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.0833
p.R219W	DO37471	SKCM	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.0833
p.R211C	TCGA-EO-A22T	UCEC	TCGA	LPKTPVSS	DEG_SCF_FBW7_1	0.3056
p.R211C	DO42320	UCEC	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.3056
p.R212H	TCGA-G5-6233	READ	TCGA	LPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.R212H	DO36626	READ	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.E193K	TCGA-IR-A3LF	CESC	TCGA	LPKTPVSS	DEG_SCF_FBW7_1	0.0556
p.E193K	DO44279	CESC	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.0556
p.Q202H	TCGA-K4-A5RJ	BLCA	TCGA	LPKTPVSS	DEG_SCF_FBW7_1	0.3056
p.Q202H	DO49784	BLCA	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.3056
p.L203I	TCGA-K4-A5RJ	BLCA	TCGA	LPKTPVSS	DEG_SCF_FBW7_1	0.6063
p.L203I	DO49784	BLCA	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.6063
p.R200H	TCGA-NH-A5IV	COAD	TCGA	LPKTPVSS	DEG_SCF_FBW7_1	0.25
p.R200H	DO49095	COAD	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.25
p.R200H	SIDM00596	Endometrial Carcinoma	GDSC	LPKTPVSS	DEG_SCF_FBW7_1	0.25
p.R200H	ACH-000941	Endometrial/Uterine Cancer	CCLE	LPKTPVSS	DEG_SCF_FBW7_1	0.25
p.R200H	ACH-000954	Endometrial/Uterine Cancer	CCLE	LPKTPVSS	DEG_SCF_FBW7_1	0.25
p.R200H	ACH-001517	Endometrial/Uterine Cancer	CCLE	LPKTPVSS	DEG_SCF_FBW7_1	0.25
p.R200H	HEC-1	endometrium	COSMIC	LPKTPVSS	DEG_SCF_FBW7_1	0.25
p.T194S	DO224687	BRCA	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.0833
p.P204S	DO233694	GACA	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.5641
p.P204S	DO222632	MELA	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.5641
p.R200L	DO229031	LICA	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.25
p.L203P	DO229053	LICA	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.6471
p.R219L	DO224638	LUSC	ICGC	LPKTPVSS	DEG_SCF_FBW7_1	0.0833
p.P195Q	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	LPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.P195Q	ACH-001363	Lung Cancer	CCLE	LPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.P195Q	NCI-H2135	lung	COSMIC	LPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.R211L	SIDM00301	Pancreatic Carcinoma	GDSC	LPKTPVSS	DEG_SCF_FBW7_1	0.3056
p.R211L	SIDM00256	Neuroblastoma	GDSC	LPKTPVSS	DEG_SCF_FBW7_1	0.3056
p.R211L	ACH-000265	Pancreatic Cancer	CCLE	LPKTPVSS	DEG_SCF_FBW7_1	0.3056
p.R211L	ACH-002281	Neuroblastoma	CCLE	LPKTPVSS	DEG_SCF_FBW7_1	0.3056
p.R211L	NB14	autonomic_ganglia	COSMIC	LPKTPVSS	DEG_SCF_FBW7_1	0.3056
p.R211L	KP-4	pancreas	COSMIC	LPKTPVSS	DEG_SCF_FBW7_1	0.3056
p.R219P	SIDM00301	Pancreatic Carcinoma	GDSC	LPKTPVSS	DEG_SCF_FBW7_1	0.0833
p.R219P	ACH-000265	Pancreatic Cancer	CCLE	LPKTPVSS	DEG_SCF_FBW7_1	0.0833
p.R219P	KP-4	pancreas	COSMIC	LPKTPVSS	DEG_SCF_FBW7_1	0.0833
p.P207R	SIDM00256	Neuroblastoma	GDSC	LPKTPVSS	DEG_SCF_FBW7_1	0.7512
p.P207R	NB14	autonomic_ganglia	COSMIC	LPKTPVSS	DEG_SCF_FBW7_1	0.7512

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPKTPVSS

Degron related mutations and impact score

Drug responses associated with FAM47B mutations

All proteins holding degron of LPKTPVSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NA70	Protein FAM47B	DEG_SCF_FBW7_1	203:210	LPKTPVSS	FBXW7	0.95	More...