DegronMD

Uniprot ID: Q13938

Source protein: Calcyphosin

Source gene: CAPS

Class: DEG_SIAH_1

Location: 52:60

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9917

ASA_SCORE: 72.5333

COIL: 0.8767

CONS_SCORE: 0.4703

DSS_SCORE: 0.606

HELIX: 0.0312

FCONS_SCORE: 0.8828

RIG_SCORE: 0.6856

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G60D	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	LPLATVSPG	DEG_SIAH_1	0.6087
p.G60D	NCI-H2172	lung	COSMIC	LPLATVSPG	DEG_SIAH_1	0.6087
p.A69T	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	LPLATVSPG	DEG_SIAH_1	0.0833
p.A69T	NCI-H1155	lung	COSMIC	LPLATVSPG	DEG_SIAH_1	0.0833
p.R47Q	ACH-000907	Kidney Cancer	CCLE	LPLATVSPG	DEG_SIAH_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13938	Calcyphosin	DEG_SIAH_1	52:60	LPLATVSPG	SIAH1,SIAH2,SIAH3	0.9917	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons