DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
LPLFSD
Uniprot ID:
Q9P2H0
Source protein:
Centrosomal protein of 126 kDa
Source gene:
CEP126
Class:
LIG_APCC_ABBA_1
Location:
515:520
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8419
ASA_SCORE:
73.3
COIL:
0.7493
CONS_SCORE:
0.481
DSS_SCORE:
0.3174
HELIX:
0.187
FCONS_SCORE:
1.1457
RIG_SCORE:
0.7793
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CEP126 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LPLFSD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9P2H0
Centrosomal protein of 126 kDa
LIG_APCC_ABBA_1
515:520
LPLFSD
APC,CDC20,FZR1
0.8419
More...