DegronMD

Uniprot ID: Q8WXX0

Source protein: Dynein axonemal heavy chain 7

Source gene: DNAH7

Class: DEG_SCF_FBW7_2

Location: 3699:3706

E3 ligase: FBXW7

DEGRON score: 0.732

ASA_SCORE: 56.85

COIL: 0.9148

CONS_SCORE: 0.5527

DSS_SCORE: 0.2963

HELIX: 0.0504

FCONS_SCORE: 0.9421

RIG_SCORE: 0.7916

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A3704T	TCGA-GC-A6I3	BLCA	TCGA	LPLTPAPE	DEG_SCF_FBW7_2	0.6028
p.E3694K	TCGA-AA-A00N	COAD	TCGA	LPLTPAPE	DEG_SCF_FBW7_2	0.1944
p.E3694D	SIDM00845	Burkitt's Lymphoma	GDSC	LPLTPAPE	DEG_SCF_FBW7_2	0.1944
p.D3715Y	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	LPLTPAPE	DEG_SCF_FBW7_2	0.0833
p.D3715Y	ACH-000951	Lung Cancer	CCLE	LPLTPAPE	DEG_SCF_FBW7_2	0.0833
p.D3715Y	NCI-H2342	lung	COSMIC	LPLTPAPE	DEG_SCF_FBW7_2	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXX0	Dynein axonemal heavy chain 7	DEG_SCF_FBW7_2	3699:3706	LPLTPAPE	FBXW7	0.732	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons