DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LPLTPAPE
Uniprot ID:
Q8WXX0
Source protein:
Dynein axonemal heavy chain 7
Source gene:
DNAH7
Class:
DEG_SCF_FBW7_2
Location:
3699:3706
E3 ligase:
FBXW7
DEGRON score:
0.732
ASA_SCORE:
56.85
COIL:
0.9148
CONS_SCORE:
0.5527
DSS_SCORE:
0.2963
HELIX:
0.0504
FCONS_SCORE:
0.9421
RIG_SCORE:
0.7916
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E3694K
TCGA-AA-A00N
COAD
TCGA
LPLTPAPE
DEG_SCF_FBW7_2
0.1944
p.A3704T
TCGA-GC-A6I3
BLCA
TCGA
LPLTPAPE
DEG_SCF_FBW7_2
0.6028
p.E3694D
SIDM00845
Burkitt's Lymphoma
GDSC
LPLTPAPE
DEG_SCF_FBW7_2
0.1944
p.D3715Y
SIDM00727
Non-Small Cell Lung Carcinoma
GDSC
LPLTPAPE
DEG_SCF_FBW7_2
0.0833
p.D3715Y
ACH-000951
Lung Cancer
CCLE
LPLTPAPE
DEG_SCF_FBW7_2
0.0833
p.D3715Y
NCI-H2342
lung
COSMIC
LPLTPAPE
DEG_SCF_FBW7_2
0.0833
Drug responses associated with DNAH7 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LPLTPAPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8WXX0
Dynein axonemal heavy chain 7
DEG_SCF_FBW7_2
3699:3706
LPLTPAPE
FBXW7
0.732
More...