DegronMD

Uniprot ID: Q9P2E8

Source protein: E3 ubiquitin-protein ligase MARCHF4

Source gene: MARCHF4

Class: LIG_APCC_ABBA_1

Location: 62:67

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8209

ASA_SCORE: 87.7667

COIL: 0.9257

CONS_SCORE: 0.4211

DSS_SCORE: 0.6394

HELIX: 0.0308

FCONS_SCORE: 0.8249

RIG_SCORE: 0.6273

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A60V	SIDM02064	Colorectal Carcinoma	GDSC	LPMHGD	LIG_APCC_ABBA_1	0.2778
p.P71H	SIDM01119	Other Solid Cancers	GDSC	LPMHGD	LIG_APCC_ABBA_1	0.2222
p.P71T	SIDM01119	Other Solid Cancers	GDSC	LPMHGD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2E8	E3 ubiquitin-protein ligase MARCHF4	LIG_APCC_ABBA_1	62:67	LPMHGD	APC,CDC20,FZR1	0.8209	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons