DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
LPPAHVPPT
Uniprot ID:
Q8NBZ9
Source protein:
Putative uncharacterized protein NEXN-AS1
Source gene:
NEXN-AS1
Class:
DEG_SIAH_1
Location:
175:183
E3 ligase:
SIAH1,SIAH2,SIAH3
DEGRON score:
0.9544
ASA_SCORE:
70.8667
COIL:
0.8924
CONS_SCORE:
0
DSS_SCORE:
0.6835
HELIX:
0.0361
FCONS_SCORE:
0
RIG_SCORE:
0.6124
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with NEXN-AS1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LPPAHVPPT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NBZ9
Putative uncharacterized protein NEXN-AS1
DEG_SIAH_1
175:183
LPPAHVPPT
SIAH1,SIAH2,SIAH3
0.9544
More...