DegronMD

Uniprot ID: Q5JUK2

Source protein: Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

Source gene: SOHLH1

Class: LIG_APCC_ABBA_1

Location: 216:221

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9885

ASA_SCORE: 79.1667

COIL: 0.9072

CONS_SCORE: 0.5306

DSS_SCORE: 0.3317

HELIX: 0.0288

FCONS_SCORE: 1.2049

RIG_SCORE: 0.6573

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q211H	TCGA-AJ-A3BG	UCEC	TCGA	LPPFSE	LIG_APCC_ABBA_1	0.1944
p.Q211H	DO42633	UCEC	ICGC	LPPFSE	LIG_APCC_ABBA_1	0.1944
p.V212L	TCGA-EJ-7786	PRAD	TCGA	LPPFSE	LIG_APCC_ABBA_1	0.2222
p.V212L	DO36288	PRAD	ICGC	LPPFSE	LIG_APCC_ABBA_1	0.2222
p.P217R	DO233283	GACA	ICGC	LPPFSE	LIG_APCC_ABBA_1	0.6401
p.C210G	DO218863	SKCA	ICGC	LPPFSE	LIG_APCC_ABBA_1	0.1667
p.R213Q	SIDM00731	Small Cell Lung Carcinoma	GDSC	LPPFSE	LIG_APCC_ABBA_1	0.25
p.R213Q	NCI-H2196	lung	COSMIC	LPPFSE	LIG_APCC_ABBA_1	0.25
p.P229S	ACH-001610	Brain Cancer	CCLE	LPPFSE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JUK2	Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1	LIG_APCC_ABBA_1	216:221	LPPFSE	APC,CDC20,FZR1	0.9885	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons