DegronMD

Uniprot ID: Q70SY1

Source protein: Cyclic AMP-responsive element-binding protein 3-like protein 2

Source gene: CREB3L2

Class: DEG_SCF_FBW7_1

Location: 202:209

E3 ligase: FBXW7

DEGRON score: 0.9985

ASA_SCORE: 70.5625

COIL: 0.9454

CONS_SCORE: 0.5156

DSS_SCORE: 0.7556

HELIX: 0.0295

FCONS_SCORE: 1.2153

RIG_SCORE: 0.5028

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H210Y	TCGA-DV-5566	KIRC	TCGA	LPPTPPSS	DEG_SCF_FBW7_1	0.3056
p.H210Y	DO18651	KIRC	ICGC	LPPTPPSS	DEG_SCF_FBW7_1	0.3056
p.L203F	DO228362	LICA	ICGC	LPPTPPSS	DEG_SCF_FBW7_1	0.6981
p.T213K	DO228952	LICA	ICGC	LPPTPPSS	DEG_SCF_FBW7_1	0.2222
p.P203Q	DO228985	LICA	ICGC	LPPTPPSS	DEG_SCF_FBW7_1	0.5924
p.H201N	DO229041	LICA	ICGC	LPPTPPSS	DEG_SCF_FBW7_1	0.3056
p.M208V	DO23482	LINC	ICGC	LPPTPPSS	DEG_SCF_FBW7_1	0.7208
p.S202F	DO229177	LMS	ICGC	LPPTPPSS	DEG_SCF_FBW7_1	0.7982
p.E219D	DO29368	OV	ICGC	LPPTPPSS	DEG_SCF_FBW7_1	0.0556
p.E219D	DO41235	UCEC	ICGC	LPPTPPSS	DEG_SCF_FBW7_1	0.0556
p.P207L	DO38404	STAD	ICGC	LPPTPPSS	DEG_SCF_FBW7_1	0.6471
p.P204T	SIDM02021	Esophageal Carcinoma	GDSC	LPPTPPSS	DEG_SCF_FBW7_1	0.5919
p.K193E	SIDM01450	Gastric Carcinoma	GDSC	LPPTPPSS	DEG_SCF_FBW7_1	0.1944
p.S197C	BALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	LPPTPPSS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q70SY1	Cyclic AMP-responsive element-binding protein 3-like protein 2	DEG_SCF_FBW7_1	202:209	LPPTPPSS	FBXW7	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons