DegronMD

Uniprot ID: Q8NCW5

Source protein: NAD

Source gene: NAXE

Class: LIG_APCC_ABBA_1

Location: 275:280

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7512

ASA_SCORE: 65.1

COIL: 0.9665

CONS_SCORE: 0.4379

DSS_SCORE: 0.2729

HELIX: 0.0178

FCONS_SCORE: 1.4231

RIG_SCORE: 0.7756

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A266T	SIDM01057	Acute Myeloid Leukemia	GDSC	LPPYPD	LIG_APCC_ABBA_1	0.0833
p.A266T	SIDM00915	Small Cell Lung Carcinoma	GDSC	LPPYPD	LIG_APCC_ABBA_1	0.0833
p.A266T	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	LPPYPD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NCW5	NAD	LIG_APCC_ABBA_1	275:280	LPPYPD	APC,CDC20,FZR1	0.7512	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons