DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
LPPYSE
Uniprot ID:
Q71H61
Source protein:
Immunoglobulin-like domain-containing receptor 2
Source gene:
ILDR2
Class:
LIG_APCC_ABBA_1
Location:
591:596
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9929
ASA_SCORE:
74.4667
COIL:
0.8735
CONS_SCORE:
0.9239
DSS_SCORE:
0.6854
HELIX:
0.1005
FCONS_SCORE:
1.7454
RIG_SCORE:
0.6945
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R601S
TCGA-WS-AB45
COAD
TCGA
LPPYSE
LIG_APCC_ABBA_1
0.1944
p.R606H
SIDM01086
B-Lymphoblastic Leukemia
GDSC
LPPYSE
LIG_APCC_ABBA_1
0.0556
Drug responses associated with ILDR2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LPPYSE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q71H61
Immunoglobulin-like domain-containing receptor 2
LIG_APCC_ABBA_1
591:596
LPPYSE
APC,CDC20,FZR1
0.9929
More...