DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
LPRTPEQE
Uniprot ID:
Q99558
Source protein:
Mitogen-activated protein kinase kinase kinase 14
Source gene:
MAP3K14
Class:
DEG_SCF_FBW7_2
Location:
165:172
E3 ligase:
FBXW7
DEGRON score:
0.9809
ASA_SCORE:
99.425
COIL:
0.8534
CONS_SCORE:
0.3287
DSS_SCORE:
0.5908
HELIX:
0.1188
FCONS_SCORE:
1.0621
RIG_SCORE:
0.6492
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T168S
SIDM00357
Small Cell Lung Carcinoma
GDSC
LPRTPEQE
DEG_SCF_FBW7_2
0.7116
p.T168S
RERF-LC-FM
lung
COSMIC
LPRTPEQE
DEG_SCF_FBW7_2
0.7116
p.C174Y
SIDM01763
Rhabdomyosarcoma
GDSC
LPRTPEQE
DEG_SCF_FBW7_2
0.2778
Drug responses associated with MAP3K14 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LPRTPEQE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q99558
Mitogen-activated protein kinase kinase kinase 14
DEG_SCF_FBW7_2
165:172
LPRTPEQE
FBXW7
0.9809
More...