DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
LPSAYVPPL
Uniprot ID:
Q86SG4
Source protein:
Putative Dresden prostate carcinoma protein 2
Source gene:
HMGN2P46
Class:
DEG_SIAH_1
Location:
58:66
E3 ligase:
SIAH1,SIAH2,SIAH3
DEGRON score:
0.9855
ASA_SCORE:
77.0222
COIL:
0.92
CONS_SCORE:
0
DSS_SCORE:
0.5119
HELIX:
0.0346
FCONS_SCORE:
0
RIG_SCORE:
0.6604
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with HMGN2P46 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LPSAYVPPL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86SG4
Putative Dresden prostate carcinoma protein 2
DEG_SIAH_1
58:66
LPSAYVPPL
SIAH1,SIAH2,SIAH3
0.9855
More...