DegronMD

Uniprot ID: Q9Y3S1

Source protein: Serine/threonine-protein kinase WNK2

Source gene: WNK2

Class: DEG_SIAH_1

Location: 820:828

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9788

ASA_SCORE: 87.2889

COIL: 0.9638

CONS_SCORE: 0.4348

DSS_SCORE: 0.4576

HELIX: 0.0129

FCONS_SCORE: 1.1304

RIG_SCORE: 0.6835

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P814L	TCGA-EB-A41A	SKCM	TCGA	LPTATVPPV	DEG_SIAH_1	0.1667
p.P814S	TCGA-FW-A3R5	SKCM	TCGA	LPTATVPPV	DEG_SIAH_1	0.1667
p.D833H	DO50342	ESAD	ICGC	LPTATVPPV	DEG_SIAH_1	0.1944
p.K829N	DO229018	LICA	ICGC	LPTATVPPV	DEG_SIAH_1	0.3056
p.K829N	DO229008	LICA	ICGC	LPTATVPPV	DEG_SIAH_1	0.3056
p.T820M	DO23356	LINC	ICGC	LPTATVPPV	DEG_SIAH_1	0.7423
p.G810V	DO37782	SKCM	ICGC	LPTATVPPV	DEG_SIAH_1	0.0556
p.M825I	DO38177	SKCM	ICGC	LPTATVPPV	DEG_SIAH_1	0.7618
p.P826H	ACH-000933	Pancreatic Cancer	CCLE	LPTATVPPV	DEG_SIAH_1	0.6583

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SIAH_1	820:828	LPTATVPPV	SIAH1,SIAH2,SIAH3	0.9788	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons