DegronMD

Uniprot ID: Q92538

Source protein: Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

Source gene: GBF1

Class: DEG_SCF_FBW7_1

Location: 249:255

E3 ligase: FBXW7

DEGRON score: 0.9288

ASA_SCORE: 75.2

COIL: 0.905

CONS_SCORE: 0.2066

DSS_SCORE: 0.6773

HELIX: 0.0233

FCONS_SCORE: 0.9297

RIG_SCORE: 0.6091

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T256I	TCGA-24-1845	OV	TCGA	LPTPNGT	DEG_SCF_FBW7_1	0.3056
p.T256I	DO29920	OV	ICGC	LPTPNGT	DEG_SCF_FBW7_1	0.3056
p.M240I	TCGA-4G-AAZO	CHOL	TCGA	LPTPNGT	DEG_SCF_FBW7_1	0.0833
p.M240T	DO228947	LICA	ICGC	LPTPNGT	DEG_SCF_FBW7_1	0.0833
p.S258L	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	LPTPNGT	DEG_SCF_FBW7_1	0.25
p.S258L	ACH-000945	Lung Cancer	CCLE	LPTPNGT	DEG_SCF_FBW7_1	0.25
p.S258L	NCI-H650	lung	COSMIC	LPTPNGT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92538	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1	DEG_SCF_FBW7_1	249:255	LPTPNGT	FBXW7	0.9288	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons