DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
LPTPPAS
Uniprot ID:
A2VEC9
Source protein:
SCO-spondin
Source gene:
SSPOP
Class:
DEG_SCF_FBW7_1
Location:
1534:1540
E3 ligase:
FBXW7
DEGRON score:
0.9654
ASA_SCORE:
74.4571
COIL:
0.8751
CONS_SCORE:
0.474
DSS_SCORE:
0.6014
HELIX:
0.0193
FCONS_SCORE:
1.211
RIG_SCORE:
0.5854
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with SSPOP mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LPTPPAS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A2VEC9
SCO-spondin
DEG_SCF_FBW7_1
1534:1540
LPTPPAS
FBXW7
0.9654
More...