DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
LPTPPGE
Uniprot ID:
P26640
Source protein:
Valine--tRNA ligase
Source gene:
VARS1
Class:
DEG_SCF_FBW7_2
Location:
282:288
E3 ligase:
FBXW7
DEGRON score:
0.9957
ASA_SCORE:
73.5286
COIL:
0.9449
CONS_SCORE:
0.2755
DSS_SCORE:
0.6852
HELIX:
0.0157
FCONS_SCORE:
0.9797
RIG_SCORE:
0.6299
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with VARS1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LPTPPGE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P26640
Valine--tRNA ligase
DEG_SCF_FBW7_2
282:288
LPTPPGE
FBXW7
0.9957
More...