DegronMD

Uniprot ID: Q7Z4T9

Source protein: Cilia- and flagella-associated protein 91

Source gene: CFAP91

Class: DEG_SCF_FBW7_2

Location: 477:483

E3 ligase: FBXW7

DEGRON score: 0.7983

ASA_SCORE: 87.4286

COIL: 0.8816

CONS_SCORE: 0.5937

DSS_SCORE: 0.6689

HELIX: 0.0257

FCONS_SCORE: 1.1575

RIG_SCORE: 0.6857

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P478S	SIDM00107	Melanoma	GDSC	LPTPTLE	DEG_SCF_FBW7_2	0.5641
p.R476Q	SIDM00602	Gastric Carcinoma	GDSC	LPTPTLE	DEG_SCF_FBW7_2	0.3056
p.R476Q	SIDM00596	Endometrial Carcinoma	GDSC	LPTPTLE	DEG_SCF_FBW7_2	0.3056
p.R476W	SIDM00549	B-Lymphoblastic Leukemia	GDSC	LPTPTLE	DEG_SCF_FBW7_2	0.3056
p.R476W	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	LPTPTLE	DEG_SCF_FBW7_2	0.3056
p.R476W	SIDM00381	Cervical Carcinoma	GDSC	LPTPTLE	DEG_SCF_FBW7_2	0.3056
p.R476W	SIDM01753	Gastric Carcinoma	GDSC	LPTPTLE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z4T9	Cilia- and flagella-associated protein 91	DEG_SCF_FBW7_2	477:483	LPTPTLE	FBXW7	0.7983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons