DegronMD

Uniprot ID: P23396

Source protein: 40S ribosomal protein S3

Source gene: RPS3

Class: DEG_SCF_FBW7_2

Location: 218:225

E3 ligase: FBXW7

DEGRON score: 0.9743

ASA_SCORE: 86.575

COIL: 0.9236

CONS_SCORE: 0.2635

DSS_SCORE: 0.7558

HELIX: 0.0274

FCONS_SCORE: 0.8148

RIG_SCORE: 0.675

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G215A	TCGA-69-8255	LUAD	TCGA	LPTTPISE	DEG_SCF_FBW7_2	0.25
p.H223R	TCGA-97-7938	LUAD	TCGA	LPTTPISE	DEG_SCF_FBW7_2	0.8244
p.D222N	TCGA-D1-A160	UCEC	TCGA	LPTTPISE	DEG_SCF_FBW7_2	0.6932
p.I214V	TCGA-HU-8608	STAD	TCGA	LPTTPISE	DEG_SCF_FBW7_2	0.6667
p.P229L	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LPTTPISE	DEG_SCF_FBW7_2	0.2222
p.P229L	ACH-001127	Leukemia	CCLE	LPTTPISE	DEG_SCF_FBW7_2	0.2222
p.P229L	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LPTTPISE	DEG_SCF_FBW7_2	0.2222
p.D231V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LPTTPISE	DEG_SCF_FBW7_2	0.1667
p.D231V	ACH-001127	Leukemia	CCLE	LPTTPISE	DEG_SCF_FBW7_2	0.1667
p.D231V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LPTTPISE	DEG_SCF_FBW7_2	0.1667
p.M224V	MFE-280	endometrium	COSMIC	LPTTPISE	DEG_SCF_FBW7_2	0.7208
p.D215V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LPTTPISE	DEG_SCF_FBW7_2	0.25
p.P221L	OS-RC-2	kidney	COSMIC	LPTTPISE	DEG_SCF_FBW7_2	0.7582
p.V228F	TGW	autonomic_ganglia	COSMIC	LPTTPISE	DEG_SCF_FBW7_2	0.25
p.P213L	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LPTTPISE	DEG_SCF_FBW7_2	0.1944
p.P233L	OS-RC-2	kidney	COSMIC	LPTTPISE	DEG_SCF_FBW7_2	0.1111
p.P229R	NB14	autonomic_ganglia	COSMIC	LPTTPISE	DEG_SCF_FBW7_2	0.2222
p.M224T	OCUM-1	stomach	COSMIC	LPTTPISE	DEG_SCF_FBW7_2	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23396	40S ribosomal protein S3	DEG_SCF_FBW7_2	218:225	LPTTPISE	FBXW7	0.9743	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons