DegronMD

Uniprot ID: A6NK53

Source protein: Zinc finger protein 233

Source gene: ZNF233

Class: SCF_FBXL2

Location: 413:422

E3 ligase: FBXL2

DEGRON score: 0.7852

ASA_SCORE: 70.64

COIL: 0.6999

CONS_SCORE: 0.4133

DSS_SCORE: 0.4976

HELIX: 0.0833

FCONS_SCORE: 1.5299

RIG_SCORE: 0.6812

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R418K	TCGA-26-1442	GBM	TCGA	LQAHQRGHSR	SCF_FBXL2	0.7237
p.R418K	DO12802	GBM	ICGC	LQAHQRGHSR	SCF_FBXL2	0.7237
p.V430A	TCGA-2W-A8YY	CESC	TCGA	LQAHQRGHSR	SCF_FBXL2	0.1111
p.V430A	DO223732	CESC	ICGC	LQAHQRGHSR	SCF_FBXL2	0.1111
p.W428L	TCGA-66-2788	LUSC	TCGA	LQAHQRGHSR	SCF_FBXL2	0.1667
p.W428L	DO26749	LUSC	ICGC	LQAHQRGHSR	SCF_FBXL2	0.1667
p.T410P	TCGA-69-7974	LUAD	TCGA	LQAHQRGHSR	SCF_FBXL2	0.25
p.T410P	DO23850	LUAD	ICGC	LQAHQRGHSR	SCF_FBXL2	0.25
p.E429D	DO15591	HNSC	ICGC	LQAHQRGHSR	SCF_FBXL2	0.1389
p.G406V	DO229041	LICA	ICGC	LQAHQRGHSR	SCF_FBXL2	0.1389
p.R422S	SIDM00837	Colorectal Carcinoma	GDSC	LQAHQRGHSR	SCF_FBXL2	0.7427
p.R422S	ACH-000958	Colon/Colorectal Cancer	CCLE	LQAHQRGHSR	SCF_FBXL2	0.7427
p.R422S	SW48	large_intestine	COSMIC	LQAHQRGHSR	SCF_FBXL2	0.7427
p.Y403D	SIDM00414	Bladder Carcinoma	GDSC	LQAHQRGHSR	SCF_FBXL2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NK53	Zinc finger protein 233	SCF_FBXL2	413:422	LQAHQRGHSR	FBXL2	0.7852	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons