DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
LQCGRGVPR
Uniprot ID:
Q8N2X6
Source protein:
Uncharacterized protein EXOC3-AS1
Source gene:
EXOC3-AS1
Class:
SCF_FBXL2
Location:
13:21
E3 ligase:
FBXL2
DEGRON score:
0.5622
ASA_SCORE:
62.9222
COIL:
0.735
CONS_SCORE:
0.8888
DSS_SCORE:
0.3825
HELIX:
0.2054
FCONS_SCORE:
1.0292
RIG_SCORE:
0.6952
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with EXOC3-AS1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LQCGRGVPR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N2X6
Uncharacterized protein EXOC3-AS1
SCF_FBXL2
13:21
LQCGRGVPR
FBXL2
0.5622
More...
