DegronMD

Uniprot ID: Q16787

Source protein: Laminin subunit alpha-3

Source gene: LAMA3

Class: DEG_SCF_FBW7_1

Location: 2956:2963

E3 ligase: FBXW7

DEGRON score: 0.6196

ASA_SCORE: 89.525

COIL: 0.8653

CONS_SCORE: 0.2879

DSS_SCORE: 0.3772

HELIX: 0.0932

FCONS_SCORE: 1.0308

RIG_SCORE: 0.774

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2973D	TCGA-19-5956	GBM	TCGA	LQDTPVAS	DEG_SCF_FBW7_1	0.0556
p.L2955V	TCGA-36-2547	OV	TCGA	LQDTPVAS	DEG_SCF_FBW7_1	0.3056
p.R2951H	TCGA-AP-A0LM	UCEC	TCGA	LQDTPVAS	DEG_SCF_FBW7_1	0.1944
p.R2951H	DO43306	UCEC	ICGC	LQDTPVAS	DEG_SCF_FBW7_1	0.1944
p.R2951H	ACH-001030	Bone Cancer	CCLE	LQDTPVAS	DEG_SCF_FBW7_1	0.1944
p.R2951H	ACH-001412	Bladder Cancer	CCLE	LQDTPVAS	DEG_SCF_FBW7_1	0.1944
p.R2951C	TCGA-EB-A44O	SKCM	TCGA	LQDTPVAS	DEG_SCF_FBW7_1	0.1944
p.R2951C	DO222702	MELA	ICGC	LQDTPVAS	DEG_SCF_FBW7_1	0.1944
p.R2951C	DO47272	SKCM	ICGC	LQDTPVAS	DEG_SCF_FBW7_1	0.1944
p.R2951C	SIDM00521	Small Cell Lung Carcinoma	GDSC	LQDTPVAS	DEG_SCF_FBW7_1	0.1944
p.R2951C	SIDM00705	Non-Cancerous	GDSC	LQDTPVAS	DEG_SCF_FBW7_1	0.1944
p.R2951C	SIDM00696	Non-Cancerous	GDSC	LQDTPVAS	DEG_SCF_FBW7_1	0.1944
p.R2951C	SIDM00772	Breast Carcinoma	GDSC	LQDTPVAS	DEG_SCF_FBW7_1	0.1944
p.R2951C	SIDM01191	Osteosarcoma	GDSC	LQDTPVAS	DEG_SCF_FBW7_1	0.1944
p.R2951C	SIDM01503	Small Cell Lung Carcinoma	GDSC	LQDTPVAS	DEG_SCF_FBW7_1	0.1944
p.R2951C	SIDM01765	Osteosarcoma	GDSC	LQDTPVAS	DEG_SCF_FBW7_1	0.1944
p.K2946N	DO229218	THCA	ICGC	LQDTPVAS	DEG_SCF_FBW7_1	0.1667
p.A2962V	SIDM01126	Small Cell Lung Carcinoma	GDSC	LQDTPVAS	DEG_SCF_FBW7_1	0.5825
p.A2962V	SIDM00282	Colorectal Carcinoma	GDSC	LQDTPVAS	DEG_SCF_FBW7_1	0.5825
p.A2962V	ACH-000998	Colon/Colorectal Cancer	CCLE	LQDTPVAS	DEG_SCF_FBW7_1	0.5825
p.A2962V	ACH-001599	Lung Cancer	CCLE	LQDTPVAS	DEG_SCF_FBW7_1	0.5825
p.A2962V	NCI-H64	lung	COSMIC	LQDTPVAS	DEG_SCF_FBW7_1	0.5825
p.A2962V	CW-2	large_intestine	COSMIC	LQDTPVAS	DEG_SCF_FBW7_1	0.5825
p.V2967M	SIDM00846	Cervical Carcinoma	GDSC	LQDTPVAS	DEG_SCF_FBW7_1	0.2222
p.V2967M	ACH-001086	Cervical Cancer	CCLE	LQDTPVAS	DEG_SCF_FBW7_1	0.2222
p.V2967M	HeLa	cervix	COSMIC	LQDTPVAS	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LQDTPVAS

Degron related mutations and impact score

Drug responses associated with LAMA3 mutations

All proteins holding degron of LQDTPVAS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16787	Laminin subunit alpha-3	DEG_SCF_FBW7_1	2956:2963	LQDTPVAS	FBXW7	0.6196	More...