DegronMD

Uniprot ID: Q86WZ6

Source protein: Zinc finger protein 227

Source gene: ZNF227

Class: LIG_APCC_ABBA_1

Location: 201:206

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9762

ASA_SCORE: 77.1833

COIL: 0.7228

CONS_SCORE: 0.5027

DSS_SCORE: 0.4958

HELIX: 0.1597

FCONS_SCORE: 0.8983

RIG_SCORE: 0.7913

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K193Q	TCGA-50-5049	LUAD	TCGA	LQIHED	LIG_APCC_ABBA_1	0.2222
p.K209N	TCGA-AX-A05Z	UCEC	TCGA	LQIHED	LIG_APCC_ABBA_1	0.3611
p.P212Q	TCGA-D3-A3C7	SKCM	TCGA	LQIHED	LIG_APCC_ABBA_1	0.1667
p.P212Q	DO47569	SKCM	ICGC	LQIHED	LIG_APCC_ABBA_1	0.1667
p.H214Y	TCGA-GN-A4U4	SKCM	TCGA	LQIHED	LIG_APCC_ABBA_1	0.1111
p.P193L	DO222632	MELA	ICGC	LQIHED	LIG_APCC_ABBA_1	0.2222
p.P193L	DO37571	SKCM	ICGC	LQIHED	LIG_APCC_ABBA_1	0.2222
p.G202C	DO37901	SKCM	ICGC	LQIHED	LIG_APCC_ABBA_1	0.76
p.Q194R	SIDM01229	Neuroblastoma	GDSC	LQIHED	LIG_APCC_ABBA_1	0.1389
p.Q194R	ACH-000312	Neuroblastoma	CCLE	LQIHED	LIG_APCC_ABBA_1	0.1389
p.Q194R	ACH-002217	Neuroblastoma	CCLE	LQIHED	LIG_APCC_ABBA_1	0.1389
p.Q194R	BE2-M17	autonomic_ganglia	COSMIC	LQIHED	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86WZ6	Zinc finger protein 227	LIG_APCC_ABBA_1	201:206	LQIHED	APC,CDC20,FZR1	0.9762	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons