DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LQITPPIS
Uniprot ID:
Q6ICC9
Source protein:
Retrotransposon Gag-like protein 6
Source gene:
RTL6
Class:
DEG_SCF_FBW7_1
Location:
77:84
E3 ligase:
FBXW7
DEGRON score:
0.972
ASA_SCORE:
94.55
COIL:
0.9536
CONS_SCORE:
0.9936
DSS_SCORE:
0.517
HELIX:
0.0194
FCONS_SCORE:
1.0006
RIG_SCORE:
0.7213
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with RTL6 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LQITPPIS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6ICC9
Retrotransposon Gag-like protein 6
DEG_SCF_FBW7_1
77:84
LQITPPIS
FBXW7
0.972
More...