DegronMD

Uniprot ID: O75417

Source protein: DNA polymerase theta

Source gene: POLQ

Class: LIG_APCC_ABBA_1

Location: 2536:2541

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7515

ASA_SCORE: 50.3167

COIL: 0.5108

CONS_SCORE: 0.5194

DSS_SCORE: 0.0273

HELIX: 0.1777

FCONS_SCORE: 1.5115

RIG_SCORE: 0.9275

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H2539Y	TCGA-D6-6516	HNSC	TCGA	LQLHDE	LIG_APCC_ABBA_1	0.6118
p.H2539Y	DO15623	HNSC	ICGC	LQLHDE	LIG_APCC_ABBA_1	0.6118
p.F2533V	TCGA-DK-AA71	BLCA	TCGA	LQLHDE	LIG_APCC_ABBA_1	0.25
p.F2533V	DO219010	BLCA	ICGC	LQLHDE	LIG_APCC_ABBA_1	0.25
p.E2548D	TCGA-MP-A4SV	LUAD	TCGA	LQLHDE	LIG_APCC_ABBA_1	0.1389
p.E2548D	DO45339	LUAD	ICGC	LQLHDE	LIG_APCC_ABBA_1	0.1389
p.A2547T	DO233855	GACA	ICGC	LQLHDE	LIG_APCC_ABBA_1	0.1667
p.A2547V	DO229505	LAML	ICGC	LQLHDE	LIG_APCC_ABBA_1	0.1667
p.V2551D	SIDM00003	Melanoma	GDSC	LQLHDE	LIG_APCC_ABBA_1	0.0556
p.V2551D	ACH-000884	Skin Cancer	CCLE	LQLHDE	LIG_APCC_ABBA_1	0.0556
p.V2551D	ACH-002159	Skin Cancer	CCLE	LQLHDE	LIG_APCC_ABBA_1	0.0556
p.V2551D	M14	skin	COSMIC	LQLHDE	LIG_APCC_ABBA_1	0.0556
p.G2527E	HCT-15	large_intestine	COSMIC	LQLHDE	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75417	DNA polymerase theta	LIG_APCC_ABBA_1	2536:2541	LQLHDE	APC,CDC20,FZR1	0.7515	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons