DegronMD

Uniprot ID: O75417

Source protein: DNA polymerase theta

Source gene: POLQ

Class: DEG_SCF_FBW7_1

Location: 1813:1820

E3 ligase: FBXW7

DEGRON score: 0.7484

ASA_SCORE: 72.6125

COIL: 0.8125

CONS_SCORE: 0.2671

DSS_SCORE: 0.4116

HELIX: 0.0701

FCONS_SCORE: 0.9481

RIG_SCORE: 0.6715

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1808S	TCGA-KK-A6E3	PRAD	TCGA	LQLTPASS	DEG_SCF_FBW7_1	0.1944
p.L1808S	DO51357	PRAD	ICGC	LQLTPASS	DEG_SCF_FBW7_1	0.1944
p.V1830L	TCGA-NC-A5HI	LUSC	TCGA	LQLTPASS	DEG_SCF_FBW7_1	0.0556
p.V1830L	DO45461	LUSC	ICGC	LQLTPASS	DEG_SCF_FBW7_1	0.0556
p.S1805L	TCGA-TN-A7HL	HNSC	TCGA	LQLTPASS	DEG_SCF_FBW7_1	0.1111
p.S1805L	DO219080	HNSC	ICGC	LQLTPASS	DEG_SCF_FBW7_1	0.1111
p.L1813S	DO225346	BRCA	ICGC	LQLTPASS	DEG_SCF_FBW7_1	0.7667
p.A1818D	DO229041	LICA	ICGC	LQLTPASS	DEG_SCF_FBW7_1	0.6682
p.S1824N	DO23524	LIRI	ICGC	LQLTPASS	DEG_SCF_FBW7_1	0.2222
p.P1817A	SIDM00841	Colorectal Carcinoma	GDSC	LQLTPASS	DEG_SCF_FBW7_1	0.7503
p.P1817A	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	LQLTPASS	DEG_SCF_FBW7_1	0.7503
p.P1817A	ACH-000651	Colon/Colorectal Cancer	CCLE	LQLTPASS	DEG_SCF_FBW7_1	0.7503
p.P1817A	ACH-000717	Esophageal Cancer	CCLE	LQLTPASS	DEG_SCF_FBW7_1	0.7503
p.P1817A	COLO-680N	oesophagus	COSMIC	LQLTPASS	DEG_SCF_FBW7_1	0.7503
p.P1817A	SW620	large_intestine	COSMIC	LQLTPASS	DEG_SCF_FBW7_1	0.7503
p.R1805I	SNU-81	large_intestine	COSMIC	LQLTPASS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75417	DNA polymerase theta	DEG_SCF_FBW7_1	1813:1820	LQLTPASS	FBXW7	0.7484	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons