DegronMD

Uniprot ID: P54257

Source protein: Huntingtin-associated protein 1

Source gene: HAP1

Class: LIG_APCC_ABBA_1

Location: 253:258

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9515

ASA_SCORE: 101.95

COIL: 0.4163

CONS_SCORE: 0.9228

DSS_SCORE: 0.6595

HELIX: 0.5752

FCONS_SCORE: 1.2744

RIG_SCORE: 0.7141

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R257W	DO225337	BRCA	ICGC	LQLYSD	LIG_APCC_ABBA_1	0.8634
p.Y256S	SIDM01004	Chronic Myelogenous Leukemia	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SIDM00216	Colorectal Carcinoma	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SIDM00075	Non-Cancerous	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SIDM00193	Colorectal Carcinoma	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SIDM00267	Biliary Tract Carcinoma	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SIDM00590	Oral Cavity Carcinoma	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SIDM00293	Small Cell Lung Carcinoma	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SIDM00251	Gastric Carcinoma	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SIDM00489	Oral Cavity Carcinoma	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SIDM00273	Glioblastoma	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SIDM00171	Colorectal Carcinoma	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SNU-175	large_intestine	COSMIC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SNU-81	large_intestine	COSMIC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.D258N	DO26790	LUSC	ICGC	LQLYSD	LIG_APCC_ABBA_1	0.6932
p.H252Y	LU-99A	lung	COSMIC	LQLYSD	LIG_APCC_ABBA_1	0.3056
p.D250N	TCGA-33-4566	LUSC	TCGA	LQLYSD	LIG_APCC_ABBA_1	0.25
p.E262K	TCGA-FW-A3R5	SKCM	TCGA	LQLYSD	LIG_APCC_ABBA_1	0.2222
p.Q262H	DO228422	LICA	ICGC	LQLYSD	LIG_APCC_ABBA_1	0.2222
p.Y264S	SNU-81	large_intestine	COSMIC	LQLYSD	LIG_APCC_ABBA_1	0.1667
p.Y264S	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	LQLYSD	LIG_APCC_ABBA_1	0.1667
p.Y264S	SNU-175	large_intestine	COSMIC	LQLYSD	LIG_APCC_ABBA_1	0.1667
p.E245K	DO27074	LUSC	ICGC	LQLYSD	LIG_APCC_ABBA_1	0.1111

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Drug responses associated with HAP1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of LQLYSD

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54257	Huntingtin-associated protein 1	LIG_APCC_ABBA_1	253:258	LQLYSD	APC,CDC20,FZR1	0.9515	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LQLYSD

Degron related mutations and impact score

Drug responses associated with HAP1 mutations

All proteins holding degron of LQLYSD