DegronMD

Uniprot ID: P54257

Source protein: Huntingtin-associated protein 1

Source gene: HAP1

Class: LIG_APCC_ABBA_1

Location: 253:258

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9515

ASA_SCORE: 101.95

COIL: 0.4163

CONS_SCORE: 0.9228

DSS_SCORE: 0.6595

HELIX: 0.5752

FCONS_SCORE: 1.2744

RIG_SCORE: 0.7141

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D250N	TCGA-33-4566	LUSC	TCGA	LQLYSD	LIG_APCC_ABBA_1	0.25
p.E262K	TCGA-FW-A3R5	SKCM	TCGA	LQLYSD	LIG_APCC_ABBA_1	0.2222
p.R257W	DO225337	BRCA	ICGC	LQLYSD	LIG_APCC_ABBA_1	0.8634
p.Q262H	DO228422	LICA	ICGC	LQLYSD	LIG_APCC_ABBA_1	0.2222
p.D258N	DO26790	LUSC	ICGC	LQLYSD	LIG_APCC_ABBA_1	0.6932
p.E245K	DO27074	LUSC	ICGC	LQLYSD	LIG_APCC_ABBA_1	0.1111
p.E245K	DO220239	SARC	ICGC	LQLYSD	LIG_APCC_ABBA_1	0.1111
p.A243V	DO220899	MELA	ICGC	LQLYSD	LIG_APCC_ABBA_1	0.0556
p.Y256S	SIDM01004	Chronic Myelogenous Leukemia	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SIDM00216	Colorectal Carcinoma	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SIDM00075	Non-Cancerous	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SIDM00193	Colorectal Carcinoma	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SIDM00267	Biliary Tract Carcinoma	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SIDM00590	Oral Cavity Carcinoma	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SIDM00293	Small Cell Lung Carcinoma	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SIDM00251	Gastric Carcinoma	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SIDM00489	Oral Cavity Carcinoma	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SIDM00273	Glioblastoma	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SIDM00171	Colorectal Carcinoma	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SNU-175	large_intestine	COSMIC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.Y256S	SNU-81	large_intestine	COSMIC	LQLYSD	LIG_APCC_ABBA_1	0.712
p.H244Y	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	LQLYSD	LIG_APCC_ABBA_1	0.0833
p.H244Y	LU-99A	lung	COSMIC	LQLYSD	LIG_APCC_ABBA_1	0.0833
p.H252Y	LU-99A	lung	COSMIC	LQLYSD	LIG_APCC_ABBA_1	0.3056
p.Y264S	SNU-81	large_intestine	COSMIC	LQLYSD	LIG_APCC_ABBA_1	0.1667
p.Y264S	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	LQLYSD	LIG_APCC_ABBA_1	0.1667
p.Y264S	SNU-175	large_intestine	COSMIC	LQLYSD	LIG_APCC_ABBA_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LQLYSD

Degron related mutations and impact score

Drug responses associated with HAP1 mutations

All proteins holding degron of LQLYSD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54257	Huntingtin-associated protein 1	LIG_APCC_ABBA_1	253:258	LQLYSD	APC,CDC20,FZR1	0.9515	More...