DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
LQNLRGGR
Uniprot ID:
P0C7X4
Source protein:
Putative ferritin heavy polypeptide-like 19
Source gene:
FTH1P19
Class:
SCF_FBXL2
Location:
36:43
E3 ligase:
FBXL2
DEGRON score:
0.5674
ASA_SCORE:
61.7625
COIL:
0.6109
CONS_SCORE:
0.6835
DSS_SCORE:
0.246
HELIX:
0.2343
FCONS_SCORE:
1.2948
RIG_SCORE:
0.738
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with FTH1P19 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LQNLRGGR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P0C7X4
Putative ferritin heavy polypeptide-like 19
SCF_FBXL2
36:43
LQNLRGGR
FBXL2
0.5674
More...
