DegronMD

Uniprot ID: O43353

Source protein: Receptor-interacting serine/threonine-protein kinase 2

Source gene: RIPK2

Class: LIG_APCC_ABBA_1

Location: 517:522

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.999

ASA_SCORE: 72.7333

COIL: 0.8225

CONS_SCORE: 0.6832

DSS_SCORE: 0.3317

HELIX: 0.0315

FCONS_SCORE: 0.9855

RIG_SCORE: 0.8009

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S529P	TCGA-CH-5762	PRAD	TCGA	LQPYPE	LIG_APCC_ABBA_1	0.5833
p.S529L	TCGA-MV-A51V	BLCA	TCGA	LQPYPE	LIG_APCC_ABBA_1	0.5833
p.M515T	SIDM00396	Acute Myeloid Leukemia	GDSC	LQPYPE	LIG_APCC_ABBA_1	0.2778
p.M515T	ACH-000112	Leukemia	CCLE	LQPYPE	LIG_APCC_ABBA_1	0.2778
p.M515T	SIG-M5	haematopoietic_and_lymphoid_tissue	COSMIC	LQPYPE	LIG_APCC_ABBA_1	0.2778
p.M515I	ACH-000774	Lung Cancer	CCLE	LQPYPE	LIG_APCC_ABBA_1	0.2778
p.P530S	ACH-000973	Bladder Cancer	CCLE	LQPYPE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43353	Receptor-interacting serine/threonine-protein kinase 2	LIG_APCC_ABBA_1	517:522	LQPYPE	APC,CDC20,FZR1	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons